NDLI: An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice.

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An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice.

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An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wang, H. Sawyers, C. Gaciong, Z. Parsons, R. Yang, L. Podsypanina, K. Crane, A. Gibbons, J. Hedrick-ellenson, L. Hennessy, I. Frost, P. Politis, C. Lee, R. T. Puc, J. Neshat, M. Blenis, J. Fisher, P. Dreisbach, V.
Description	Author Affiliation: Podsypanina K ( Institute of Cancer Genetics, Department of Pathology and Medicine, College of Physicians and Surgeons, Columbia University, 1150 St. Nicholas Avenue, Russ Berrie Pavilion, New York, NY 10032, USA.);
Abstract	PTEN phosphatase acts as a tumor suppressor by negatively regulating the phosphoinositide 3-kinase (PI3K) signaling pathway. It is unclear which downstream components of this pathway are necessary for oncogenic transformation. In this report we show that transformed cells of PTEN(+/-) mice have elevated levels of phosphorylated Akt and activated p70/S6 kinase associated with an increase in proliferation. Pharmacological inactivation of mTOR/RAFT/FRAP reduced neoplastic proliferation, tumor size, and p70/S6 kinase activity, but did not affect the status of Akt. These data suggest that p70/S6K and possibly other targets of mTOR contribute significantly to tumor development and that inhibition of these proteins may be therapeutic for cancer patients with deranged PI3K signaling.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	18
Volume Number	98
Language	English
Publisher	National Academy of Sciences
Publisher Date	2001-08-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Phosphoric Monoester Hydrolases Deficiency Protein Kinase Inhibitors Protein Kinases Ribosomal Protein S6 Kinases Metabolism Tumor Suppressor Proteins Alleles Animals Cell Transformation, Neoplastic Drug Effects DNA Primers Genetics Mice Mice, Knockout PTEN Phosphohydrolase Phosphatidylinositol 3-Kinases Signal Transduction Sirolimus Analogs & Derivatives Pharmacology TOR Serine-Threonine Kinases Uterine Neoplasms Drug Therapy Pathology Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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