NDLI: The SOS response regulates adaptive mutation.

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The SOS response regulates adaptive mutation.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Lee, P. L. Rosenberg, S. M. Harris, R. S. Mckenzie, G. J.
Description	Author Affiliation: McKenzie GJ ( Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.);
Abstract	Upon starvation some Escherichia coli cells undergo a transient, genome-wide hypermutation (called adaptive mutation) that is recombination-dependent and appears to be a response to a stressful environment. Adaptive mutation may reflect an inducible mechanism that generates genetic variability in times of stress. Previously, however, the regulatory components and signal transduction pathways controlling adaptive mutation were unknown. Here we show that adaptive mutation is regulated by the SOS response, a complex, graded response to DNA damage that includes induction of gene products blocking cell division and promoting mutation, recombination, and DNA repair. We find that SOS-induced levels of proteins other than RecA are needed for adaptive mutation. We report a requirement of RecF for efficient adaptive mutation and provide evidence that the role of RecF in mutation is to allow SOS induction. We also report the discovery of an SOS-controlled inhibitor of adaptive mutation, PsiB. These results indicate that adaptive mutation is a tightly regulated response, controlled both positively and negatively by the SOS system.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	12
Volume Number	97
Language	English
Publisher	National Academy of Sciences
Publisher Date	2000-07-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Adaptation, Physiological Escherichia Coli Proteins Mutation SOS Response (Genetics) Bacterial Proteins Physiology DNA Repair DNA-Binding Proteins Regulon Serine Endopeptidases Signal Transduction Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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