NDLI: A nucleolar protein related to ribosomal protein L7 is required for an early step in large ribosomal subunit biogenesis.

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2003 Volume: 100

Year: 2002 Volume: 99

Year: 2001 Volume: 98

Year: 2000 Volume: 97

Year: 2000 Volume: 97 Issue: 26

Year: 2000 Volume: 97 Issue: 25

Year: 2000 Volume: 97 Issue: 24

Batrachotoxin alkaloids from passerine birds: a second toxic bird genus (Ifrita kowaldi) from New Guinea.

Host-parasite relatedness shown by protein fingerprinting in a brood parasitic bird.

Polyglutamine disease and neuronal cell death.

Life in extreme environments: hydrothermal vents.

Advances in random matrix theory, zeta functions, and sphere packing.

Does the granular matter?

Introduction to frontiers of science.

Independent and combined analyses of sequences from all three genomic compartments converge on the root of flowering plant phylogeny.

Dynamic expression of multiple scavenger receptor cysteine-rich genes in coelomocytes of the purple sea urchin.

A host-guest system to study structure-function relationships of membrane fusion peptides.

Effect of the protein import machinery at the mitochondrial surface on precursor stability.

UV-damage-mediated induction of homologous recombination in Arabidopsis is dependent on photosynthetically active radiation.

ROP-1, an RNA quality-control pathway component, affects Caenorhabditis elegans dauer formation.

Mice with a targeted mutation in the thyroid hormone beta receptor gene exhibit impaired growth and resistance to thyroid hormone.

Multiple quantum solid-state NMR indicates a parallel, not antiparallel, organization of beta-sheets in Alzheimer's beta-amyloid fibrils.

Role of the calcium-binding protein parvalbumin in short-term synaptic plasticity

Protective long-term antibody memory by antigen-driven and T help-dependent differentiation of long-lived memory B cells to short-lived plasma cells independent of secondary lymphoid organs.

The human sex-reversing ATRX gene has a homologue on the marsupial Y chromosome, ATRY: implications for the evolution of mammalian sex determination.

Functional cooperation between T helper cell determinants.

Phytochrome B binds with greater apparent affinity than phytochrome A to the basic helix-loop-helix factor PIF3 in a reaction requiring the PAS domain of PIF3.

Y chromosomal fertility factors kl-2 and kl-3 of Drosophila melanogaster encode dynein heavy chain polypeptides.

Posttranslational modification of the glycosylation inhibiting factor (GIF) gene product generates bioactive GIF.

Differential gene expression in p53-mediated apoptosis-resistant vs. apoptosis-sensitive tumor cell lines.

Suppressor T cells regulate the nonanergic cell population that remains after peripheral tolerance is induced to the Mls-1 antigen in T cell receptor Vbeta 8.1 transgenic mice.

Rubisco activase constrains the photosynthetic potential of leaves at high temperature and $CO_{2}$

Long-term expression of gamma-globin mRNA in mouse erythrocytes from retrovirus vectors containing the human gamma-globin gene fused to the ankyrin-1 promoter.

Induction of tolerance to immunogenic tumor antigens associated with lymphomagenesis in HOX11 transgenic mice.

Pax8 has a key role in thyroid cell differentiation.

Regulation of apoptosis at cell division by $p34^{cdc2}$ phosphorylation of survivin

A CBF5 mutation that disrupts nucleolar localization of early tRNA biosynthesis in yeast also suppresses tRNA gene-mediated transcriptional silencing

Apical sorting of a voltage- and $Ca^{2+}-activated$ $K^{+}$ channel α-subunit in Madin-Darby canine kidney cells is independent of N-glycosylation

A cyclin-dependent kinase-activating kinase regulates differentiation of root initial cells in Arabidopsis.

The role of prefrontal cortex and posterior parietal cortex in task switching.

A mutant allele of essential, general translation initiation factor DED1 selectively inhibits translation of a viral mRNA.

Gene-experience interaction alters the cholinergic septohippocampal pathway of mice.

Manipulation of the phenolic chemistry of willows by gall-inducing sawflies.

Molecular phylogenetic analysis of evolutionary trends in stonefly wing structure and locomotor behavior.

Correlated effects of sperm competition and postmating female mortality

Virus-encoded suppressor of posttranscriptional gene silencing targets a maintenance step in the silencing pathway.

Subgenome chromosome walking in wheat: a 450-kb physical contig in Triticum monococcum L. spans the Lr10 resistance locus in hexaploid wheat (Triticum aestivum L.).

Survival motor neuron protein modulates neuron-specific apoptosis.

Minisatellite marker analysis of Trypanosoma brucei: reconciliation of clonal, panmictic, and epidemic population genetic structures.

Identification of the proton pathway in bacterial reaction centers: Both protons associated with reduction of $Q_{B}$ to $Q_{B}H_{2}$ share a common entry point

Genetic analysis of calcium spiking responses in nodulation mutants of Medicago truncatula.

Dissection of nodulation signaling using pea mutants defective for calcium spiking induced by nod factors and chitin oligomers.

Paired Ig-like receptor homologs in birds and mammals share a common ancestor with mammalian Fc receptors.

A dual-specificity aminoacyl-tRNA synthetase in the deep-rooted eukaryote Giardia lamblia.

Delivery of a stringent dimerizer-regulated gene expression system in a single retroviral vector.

Molecular signals required for type III secretion and translocation of the Xanthomonas campestris AvrBs2 protein to pepper plants.

Measuring the forces involved in polyvalent adhesion of uropathogenic Escherichia coli to mannose-presenting surfaces.

Hepatitis C virus lacking the hypervariable region 1 of the second envelope protein is infectious and causes acute resolving or persistent infection in chimpanzees.

The human SWI/SNF-B chromatin-remodeling complex is related to yeast rsc and localizes at kinetochores of mitotic chromosomes.

Posttranslational modification of TEL and TEL/AML1 by SUMO-1 and cell-cycle-dependent assembly into nuclear bodies.

Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1.

A chemical genomics approach toward understanding the global functions of the target of rapamycin protein (TOR).

Temporal distribution of the ganglion cell volleys in the normal rat optic nerve.

Isoprenoid biosynthesis: the evolution of two ancient and distinct pathways across genomes.

Physical reasons for the unusual alpha-helix stabilization afforded by charged or neutral polar residues in alanine-rich peptides.

A preference for own-subspecies' song guides vocal learning in a song bird.

Meiotic lamin C2: the unique amino-terminal hexapeptide GNAEGR is essential for nuclear envelope association.

Interaction of two arginine residues in lactate oxidase with the enzyme flavin: conversion of FMN to 8-formyl-FMN.

Targeted chromatin binding and histone acetylation in vivo by thyroid hormone receptor during amphibian development.

Calcium signaling and acute pancreatitis: specific response to a promiscuous messenger.

A guided tour in protein interaction space: coiled coils from the yeast proteome.

Activation of Rubisco regulates photosynthesis at high temperature and CO2.

Progress in understanding angiosperm history, success, and relationships: Darwin's abominably 'perplexing phenomenon'.

Family matters: kin selection and the evolution of conspecific brood parasitism.

Ubiquitin in retrovirus assembly: actor or bystander?

Avian chemical defense: toxic birds not of a feather.

A novel helper role for CD4 T cells.

Dangerous liaisons.

Small molecule developmental screens reveal the logic and timing of vertebrate development.

Efficiency of the u,v method of estimation.

Frequency of resistance to Bacillus thuringiensis in field populations of pink bollworm.

The design, synthesis, and evaluation of molecules that enable or enhance cellular uptake: peptoid molecular transporters.

Dynamics and folding of single two-stranded coiled-coil peptides studied by fluorescent energy transfer confocal microscopy.

A nucleolar protein related to ribosomal protein L7 is required for an early step in large ribosomal subunit biogenesis.

Identification of the vitamin K-dependent carboxylase active site: Cys-99 and Cys-450 are required for both epoxidation and carboxylation

Proteasome inhibition interferes with gag polyprotein processing, release, and maturation of HIV-1 and HIV-2.

A role for ubiquitin ligase recruitment in retrovirus release.

Ubiquitin is part of the retrovirus budding machinery.

Crystal structure of yeast initiation factor 4A, a DEAD-box RNA helicase.

Calcium-dependent enzyme activation and vacuole formation in the apical granular region of pancreatic acinar cells

Coordinate control of translation and localization of Vg1 mRNA in Xenopus oocytes.

Invariant size-frequency distributions along a latitudinal gradient in marine bivalves.

Morphological castes in a vertebrate.

A computationally directed screen identifying interacting coiled coils from Saccharomyces cerevisiae.

Mechanism for a transcriptional activator that works at the isomerization step.

Prostacyclin-mediated activation of peroxisome proliferator-activated receptor delta in colorectal cancer.

National burden of disease in India from indoor air pollution.

Acquired, nonrandom chromosomal abnormalities associated with the development of acute promyelocytic leukemia in transgenic mice.

Rational design of a global inhibitor of the virulence response in Staphylococcus aureus, based in part on localization of the site of inhibition to the receptor-histidine kinase, AgrC.

High-resolution structure of hair-cell tip links.

Capture of a protein synthesis-dependent component of long-term depression.

Remodeling of α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor subunit composition in hippocampal neurons after global ischemia

Region-specific differentiation of neural tube-derived neuronal restricted progenitor cells after heterotopic transplantation.

Requirement for the lpA1 lysophosphatidic acid receptor gene in normal suckling behavior.

The neuroprotective effect of pituitary adenylate cyclase-activating polypeptide on cerebellar granule cells is mediated through inhibition of the CED3-related cysteine protease caspase-3/CPP32.

Essential role of Glu-C66 for menaquinol oxidation indicates transmembrane electrochemical potential generation by Wolinella succinogenes fumarate reductase.

Year: 2000 Volume: 97 Issue: 23

Year: 2000 Volume: 97 Issue: 22

Year: 2000 Volume: 97 Issue: 21

Year: 2000 Volume: 97 Issue: 20

Year: 2000 Volume: 97 Issue: 19

Year: 2000 Volume: 97 Issue: 18

Year: 2000 Volume: 97 Issue: 17

Year: 2000 Volume: 97 Issue: 16

Year: 2000 Volume: 97 Issue: 15

Year: 2000 Volume: 97 Issue: 14

Year: 2000 Volume: 97 Issue: 13

Year: 2000 Volume: 97 Issue: 12

Year: 2000 Volume: 97 Issue: 11

Year: 2000 Volume: 97 Issue: 10

Year: 2000 Volume: 97 Issue: 9

Year: 2000 Volume: 97 Issue: 8

Year: 2000 Volume: 97 Issue: 7

Year: 2000 Volume: 97 Issue: 6

Year: 2000 Volume: 97 Issue: 5

Year: 2000 Volume: 97 Issue: 4

Year: 2000 Volume: 97 Issue: 3

Year: 2000 Volume: 97 Issue: 2

Year: 2000 Volume: 97 Issue: 1

Year: 1999 Volume: 96

Year: 1998 Volume: 95

Year: 1997 Volume: 94

Year: 1996 Volume: 93

Year: 1995 Volume: 92

Year: 1994 Volume: 91

Year: 1993 Volume: 90

Year: 1992 Volume: 89

Year: 1991 Volume: 88

Year: 1990 Volume: 87

Year: 1989 Volume: 86

Year: 1988 Volume: 85

Year: 1987 Volume: 84

Year: 1986 Volume: 83

Year: 1985 Volume: 82

Year: 1984 Volume: 81

Year: 1983 Volume: 80

Year: 1982 Volume: 79

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

A nucleolar protein related to ribosomal protein L7 is required for an early step in large ribosomal subunit biogenesis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Lee, S. J. Dunbar, D. A. Dragon, F. Baserga, S. J.
Description	Author Affiliation: Dunbar DA ( Departments of Therapeutic Radiology and Genetics, P. O. Box 208040, Yale University School of Medicine, New Haven, CT 06520-8040, USA.);
Abstract	The Saccharomyces cerevisiae Rlp7 protein has extensive identity and similarity to the large ribosomal subunit L7 proteins and shares an RNA-binding domain with them. Rlp7p is not a ribosomal protein; however, it is encoded by an essential gene and therefore must perform a function essential for cell growth. In this report, we show that Rlp7p is a nucleolar protein that plays a critical role in processing of precursors to the large ribosomal subunit RNAs. Pulse-chase labeling experiments with Rlp7p-depleted cells reveal that neither 5.8S(S), 5.8S(L), nor 25S is produced, indicating that both the major and minor processing pathways are affected. Analysis of processing intermediates by primer extension indicates that Rlp7p-depleted cells accumulate the 27SA(3) precursor RNA, which is normally the major substrate (85%) used to produce the 5.8S and 25S rRNAs, and the ratio of 27SB(L) to 27SB(S) precursors changes from approximately 1:8 to 8:1 (depleted cells). Because 27SA(3) is the direct precursor to 27SB(S), we conclude that Rlp7p is specifically required for the 5' to 3' exonucleolytic trimming of the 27SA(3) into the 27SB(S) precursor. As it is essential for processing in both the major and minor pathways, we propose that Rlp7p may act as a specificity factor that binds precursor rRNAs and tethers the enzymes that carry out the early 5' to 3' exonucleolytic reactions that generate the mature rRNAs. Rlp7p may also be required for the endonucleolytic cleavage in internal transcribed spacer 2 that separates the 5.8S rRNA from the 25S rRNA.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	24
Volume Number	97
Language	English
Publisher	National Academy of Sciences
Publisher Date	2000-12-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Cell Nucleolus Physiology Fungal Proteins Genetics Metabolism Ribosomal Proteins Ribosomes Saccharomyces Cerevisiae Proteins Saccharomyces Cerevisiae DNA, Fungal DNA, Ribosomal Kinetics RNA Precursors RNA, Fungal RNA, Ribosomal RNA, Ribosomal, 5.8S Ultrastructure Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in