NDLI: Targeted chromatin binding and histone acetylation in vivo by thyroid hormone receptor during amphibian development.

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Targeted chromatin binding and histone acetylation in vivo by thyroid hormone receptor during amphibian development.

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Targeted chromatin binding and histone acetylation in vivo by thyroid hormone receptor during amphibian development.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Sachs, L. M. Shi, Y. B.
Description	Author Affiliation: Sachs LM ( Unit on Molecular Morphogenesis, Laboratory of Molecular Embryology, National Institute of Child Health and Human Development, National Institutes of Health, Building 18T, Room 106, Bethesda, MD 20892-5431, USA.);
Abstract	Amphibian metamorphosis is marked by dramatic, thyroid hormone (TH)-induced changes involving gene regulation by TH receptor (TR). It has been postulated that TR-mediated gene regulation involves chromatin remodeling. In the absence of ligand, TR can repress gene expression by recruiting a histone deacetylase complex, whereas liganded TR recruits a histone acetylase complex for gene activation. Earlier studies have led us to propose a dual function model for TR during development. In premetamorphic tadpoles, unliganded TR represses transcription involving histone deacetylation. During metamorphosis, endogenous TH allows TR to activate gene expression through histone acetylation. Here using chromatin immunoprecipitation assay, we directly demonstrate TR binding to TH response genes constitutively in vivo in premetamorphic tadpoles. We further show that TH treatment leads to histone deacetylase release from TH response gene promoters. Interestingly, in whole animals, changes in histone acetylation show little correlation with the expression of TH response genes. On the other hand, in the intestine and tail, where TH response genes are known to be up-regulated more dramatically by TH than in most other organs, we demonstrate that TH treatment induces gene activation and histone H4 acetylation. These data argue for a role of histone acetylation in transcriptional regulation by TRs during amphibian development in some tissues, whereas in others changes in histone acetylation levels may play no or only a minor role, supporting the existence of important alternative mechanisms in gene regulation by TR.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	24
Volume Number	97
Language	English
Publisher	National Academy of Sciences
Publisher Date	2000-12-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Acetyltransferases Metabolism Chromatin Physiology Gene Expression Regulation, Developmental Histones Metamorphosis, Biological Receptors, Thyroid Hormone Saccharomyces Cerevisiae Proteins Thyroid Hormones Xenopus Laevis Acetylation Animals Cell Nucleus Embryo, Nonmammalian Histone Acetyltransferases Intestines Embryology Growth & Development Polymerase Chain Reaction Promoter Regions, Genetic Genetics Tail Transcriptional Activation Up-Regulation Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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