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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Wissenbach, U. Flockerzi, V. Niemeyer, B. A. Trost, C. Bergs, C. |
| Description | Author Affiliation: Niemeyer BA ( Institut für Pharmakologie und Toxikologie der Universität des Saarlandes, 66421 Homburg, Germany.); |
| Abstract | A finely tuned Ca(2+) signaling system is essential for cells to transduce extracellular stimuli, to regulate growth, and to differentiate. We have recently cloned CaT-like (CaT-L), a highly selective Ca(2+) channel closely related to the epithelial calcium channels (ECaC) and the calcium transport protein CaT1. CaT-L is expressed in selected exocrine tissues, and its expression also strikingly correlates with the malignancy of prostate cancer. The expression pattern and selective Ca(2+) permeation properties suggest an important function in Ca(2+) uptake and a role in tumor progression, but not much is known about the regulation of this subfamily of ion channels. We now demonstrate a biochemical and functional mechanism by which cells can control CaT-L activity. CaT-L is regulated by means of a unique calmodulin binding site, which, at the same time, is a target for protein kinase C-dependent phosphorylation. We show that Ca(2+)-dependent calmodulin binding to CaT-L, which facilitates channel inactivation, can be counteracted by protein kinase C-mediated phosphorylation of the calmodulin binding site. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 6 |
| Volume Number | 98 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2001-03-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Calcium Channels Metabolism Calcium-Binding Proteins Protein Kinase C Amino Acid Sequence Animals Binding Sites CHO Cells Calcium Genetics Calmodulin Cell Line Cricetinae Molecular Sequence Data Phosphorylation Recombinant Fusion Proteins TRPV Cation Channels Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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