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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Monni, R. Nguyen Khac, F. Gressin, L. Mugneret, F. Coniat, M. B. Mercher, T. Mauchauffe, M. Leblanc, T. Bernard, O. A. Dastugue, N. Berger, R. |
| Description | Author Affiliation: Mercher T ( U434 Institut National de la Santé et de la Recherche Médicale-Centre d'Etude du Polymorphisme Humain (CEPH), 27 Rue J. Dodu, 75010 Paris, France.); |
| Abstract | The recurrent t(1;22)(p13;q13) translocation is exclusively associated with infant acute megakaryoblastic leukemia. We have identified the two genes involved in this translocation. Both genes possess related sequences in the Drosophila genome. The chromosome 22 gene (megakaryocytic acute leukemia, MAL) product is predicted to be involved in chromatin organization, and the chromosome 1 gene (one twenty-two, OTT) product is related to the Drosophila split-end (spen) family of proteins. Drosophila genetic experiments identified spen as involved in connecting the Raf and Hox pathways. Because almost all of the sequences and all of the identified domains of both OTT and MAL proteins are included in the predicted fusion protein, the OTT-MAL fusion could aberrantly modulate chromatin organization, Hox differentiation pathways, or extracellular signaling. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 10 |
| Volume Number | 98 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2001-05-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Chromosomes, Human, Pair 1 Chromosomes, Human, Pair 22 Drosophila Proteins Drosophila Genetics Homeodomain Proteins Leukemia, Megakaryoblastic, Acute Nuclear Proteins Proteins RNA-Binding Proteins Translocation, Genetic Amino Acid Sequence Animals DNA Infant Molecular Sequence Data Chemistry Sequence Homology, Amino Acid Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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