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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Levine, Arnold J. Jin, Shengkan Feng, Zhaohui Zhang, Haiyan |
| Description | Author Affiliation: Feng Z ( Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, NJ 08903, USA.); |
| Abstract | Cell growth and proliferation requires an intricate coordination between the stimulatory signals arising from nutrients and growth factors and the inhibitory signals arising from intracellular and extracellular stresses. Alteration of the coordination often causes cancer. In mammals, the mTOR (mammalian target of rapamycin) protein kinase is the central node in nutrient and growth factor signaling, and p53 plays a critical role in sensing genotoxic and other stresses. The results presented here demonstrate that activation of p53 inhibits mTOR activity and regulates its downstream targets, including autophagy, a tumor suppression process. Moreover, the mechanisms by which p53 regulates mTOR involves AMP kinase activation and requires the tuberous sclerosis (TSC) 1/TSC2 complex, both of which respond to energy deprivation in cells. In addition, glucose starvation not only signals to shut down mTOR, but also results in the transient phosphorylation of the p53 protein. Thus, p53 and mTOR signaling machineries can cross-talk and coordinately regulate cell growth, proliferation, and death. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 23 |
| Volume Number | 102 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2005-06-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Protein Kinases Metabolism Signal Transduction Tumor Suppressor Protein P53 AMP-Activated Protein Kinases Animals Autophagy Enzyme Activation Fibroblasts Glucose Deficiency Mice Multienzyme Complexes Multiprotein Complexes Chemistry PTEN Phosphohydrolase Phosphoric Monoester Hydrolases Genetics Phosphorylation Phosphoserine Protein-Serine-Threonine Kinases RNA, Messenger Repressor Proteins TOR Serine-Threonine Kinases Tumor Suppressor Proteins Up-Regulation Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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