NDLI: Variable deletion and duplication at recombination junction ends: implication for staggered double-strand cleavage in class-switch recombination.

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2003 Volume: 100

Year: 2002 Volume: 99

Year: 2001 Volume: 98

Year: 2001 Volume: 98 Issue: 26

Year: 2001 Volume: 98 Issue: 25

Year: 2001 Volume: 98 Issue: 24

The anti-HIV pentameric pseudopeptide HB-19 is preferentially taken up in vivo by lymphoid organs where it forms a complex with nucleolin.

Phosphorylation of UBF at serine 388 is required for interaction with RNA polymerase I and activation of rDNA transcription.

Structural and mutational studies of the recognition of the arginine tRNA-specific major identity element, A20, by arginyl-tRNA synthetase.

Structure of trichodiene synthase from Fusarium sporotrichioides provides mechanistic inferences on the terpene cyclization cascade

Glucose and cAMP regulate the L-type pyruvate kinase gene by phosphorylation/dephosphorylation of the carbohydrate response element binding protein.

Extraordinary variation in a diversified family of immune-type receptor genes.

PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine

Assessment of the developmental totipotency of neural cells in the cerebral cortex of mouse embryo by nuclear transfer.

Regulation of cyclic peptide biosynthesis in a plant pathogenic fungus by a novel transcription factor.

Suppressed kindling epileptogenesis in mice with ectopic overexpression of galanin.

Degeneracy and complexity in biological systems.

Evolutionary route to diploidy and sex.

Paternal relatedness and age proximity regulate social relationships among adult female rhesus macaques.

Profiling the global tyrosine phosphorylation state by Src homology 2 domain binding.

Estrogen action and male fertility: Roles of the sodium/hydrogen exchanger-3 and fluid reabsorption in reproductive tract function

Regulation of membrane-type matrix metalloproteinase 1 activity by dynamin-mediated endocytosis.

Increased ability for selection of zidovudine resistance in a distinct class of wild-type HIV-1 from drug-naive persons.

Rational design of coagulation factor VIIa variants with substantially increased intrinsic activity.

Mechanism of ATP-driven electron transfer catalyzed by the benzene ring-reducing enzyme benzoyl-CoA reductase.

Bacillus subtilis arsenate reductase is structurally and functionally similar to low molecular weight protein tyrosine phosphatases.

Identification of a trafficking determinant localized to the Kv1 potassium channel pore.

Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors.

Directed polar secretion of protease from single cells of Vibrio cholerae via the type II secretion pathway.

Yeast Dam1p has a role at the kinetochore in assembly of the mitotic spindle.

JAC, a direct target of oncogenic transcription factor Jun, is involved in cell transformation and tumorigenesis.

AtHKT1 is a salt tolerance determinant that controls $Na^{+}$ entry into plant roots

Enhanced delayed-type hypersensitivity and diminished immediate-type hypersensitivity in mice lacking the inducible VPAC(2) receptor for vasoactive intestinal peptide.

Polycomb repression of flowering during early plant development.

Alzheimer's beta-secretase, beta-site amyloid precursor protein-cleaving enzyme, is responsible for cleavage secretion of a Golgi-resident sialyltransferase.

Parathyroid hormone regulates 25-hydroxyvitamin D(3)-24-hydroxylase mRNA by altering its stability.

Ryanodine sensitizes the cardiac $Ca^{2+}$ release channel (ryanodine receptor isoform 2) to $Ca^{2+}$ activation and dissociates as the channel is closed by $Ca^{2+}$ depletion

Biological clock in total darkness: the Clock/MOP3 circadian system of the blind subterranean mole rat.

Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses.

Myosin VI is a processive motor with a large step size.

The 2.0-A crystal structure of tachylectin 5A provides evidence for the common origin of the innate immunity and the blood coagulation systems.

Aquaporin 5-deficient mouse lungs are hyperresponsive to cholinergic stimulation.

Attractive and defensive functions of the ultraviolet pigments of a flower (Hypericum calycinum).

The role of ABA and the transpiration stream in the regulation of the osmotic water permeability of leaf cells.

FRAP/mTOR is required for proliferation and patterning during embryonic development in the mouse.

A major quantitative trait locus on chromosome 3 controls colitis severity in IL-10-deficient mice

Small molecules that dramatically alter multidrug resistance phenotype by modulating the substrate specificity of P-glycoprotein.

Compartmentalized autocrine signaling to cystic fibrosis transmembrane conductance regulator at the apical membrane of airway epithelial cells.

Surface organization and nanopatterning of collagen by dip-pen nanolithography.

Escaping the stem cell compartment: sustained UVB exposure allows p53-mutant keratinocytes to colonize adjacent epidermal proliferating units without incurring additional mutations.

Pause and rotation of F(1)-ATPase during catalysis.

Crystal structure of thermostable DNA photolyase: pyrimidine-dimer recognition mechanism.

X-ray analysis of an RNA tetraplex (UGGGGU)(4) with divalent Sr(2+) ions at subatomic resolution (0.61 A).

Chlamydia trachomatis cytotoxicity associated with complete and partial cytotoxin genes.

The expression of cerebellar LTD in culture is not associated with changes in AMPA-receptor kinetics, agonist affinity, or unitary conductance.

Low amplification and fast visual pigment phosphorylation as mechanisms characterizing cone photoresponses.

Fringe modulation of Jagged1-induced Notch signaling requires the action of beta 4galactosyltransferase-1.

Distinction between signaling mechanisms in lipid rafts vs. caveolae.

Evidence that androgens are the primary steroids produced by Xenopus laevis ovaries and may signal through the classical androgen receptor to promote oocyte maturation.

DNA packaging and ejection forces in bacteriophage.

Singlet exciton binding energy in poly(phenylene vinylene).

Diversity of gene expression in adenocarcinoma of the lung.

Bone morphogenetic protein 4 in the extraembryonic mesoderm is required for allantois development and the localization and survival of primordial germ cells in the mouse.

Adeno-associated virus (AAV) site-specific recombination does not require a Rep-dependent origin of replication within the AAV terminal repeat.

CD5 expression by B lymphocytes and its regulation upon Epstein–Barr virus transformation

Host cell factor requirement for hepatitis C virus enzyme maturation

The ability of inferior colliculus neurons to signal differences in interaural delay.

Synthesis of an organoinsulin molecule that can be activated by antibody catalysis.

Corticofugal modulation of duration-tuned neurons in the midbrain auditory nucleus in bats.

Maintenance of genetic integrity in frozen and freeze-dried mouse spermatozoa.

Radiocarbon evidence for maritime pioneer colonization at the origins of farming in west Mediterranean Europe.

Responses of python gastrointestinal regulatory peptides to feeding.

BAALC, the human member of a novel mammalian neuroectoderm gene lineage, is implicated in hematopoiesis and acute leukemia.

Activation of CD1d-restricted T cells protects NOD mice from developing diabetes by regulating dendritic cell subsets.

SNAP-29: a general SNARE protein that inhibits SNARE disassembly and is implicated in synaptic transmission.

Taxol biosynthesis: taxane 13 alpha-hydroxylase is a cytochrome P450-dependent monooxygenase.

Cholinergic dilation of cerebral blood vessels is abolished in M(5) muscarinic acetylcholine receptor knockout mice.

Magnetite morphology and life on Mars

Modulation of intestinal gene expression by dietary zinc status: effectiveness of cDNA arrays for expression profiling of a single nutrient deficiency.

An in vivo ESR spin-trapping study: free radical generation in rats from formate intoxication--role of the Fenton reaction.

Disruption of PPT1 or PPT2 causes neuronal ceroid lipofuscinosis in knockout mice.

The Schizosaccharomyces pombe origin recognition complex interacts with multiple AT-rich regions of the replication origin DNA by means of the AT-hook domains of the spOrc4 protein.

Decreased lipid synthesis in livers of mice with disrupted Site-1 protease gene

Activation of the Jnk signaling pathway by a dual-specificity phosphatase, JSP-1.

High refractive index substrates for fluorescence microscopy of biological interfaces with high z contrast

SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase

A molecular profile of the mouse gastric parietal cell with and without exposure to Helicobacter pylori

Mammalian myotube dedifferentiation induced by newt regeneration extract

Surface structure of the COPII-coated vesicle.

Flagellin stimulation of intestinal epithelial cells triggers CCL20-mediated migration of dendritic cells.

Conservation of methylation reprogramming in mammalian development: aberrant reprogramming in cloned embryos.

Evaluation of methods for detecting recombination from DNA sequences: computer simulations.

Terminal-repeat retrotransposons in miniature (TRIM) are involved in restructuring plant genomes.

High rate of CAD gene amplification in human cells deficient in MLH1 or MSH6.

Impairment of MAD2B-PRCC interaction in mitotic checkpoint defective t(X;1)-positive renal cell carcinomas.

Role of positively charged transmembrane segments in the insertion and assembly of mitochondrial inner-membrane proteins.

Structural basis for autoantibody recognition of phosphatidylserine-beta 2 glycoprotein I and apoptotic cells.

Helicobacter pylori arginase inhibits nitric oxide production by eukaryotic cells: a strategy for bacterial survival.

Variable deletion and duplication at recombination junction ends: implication for staggered double-strand cleavage in class-switch recombination.

Vaccination, prevention, and treatment of experimental autoimmune neuritis (EAN) by an oligomerized T cell epitope

High-level HIV-1 viremia suppresses viral antigen-specific CD4(+) T cell proliferation.

Caspase-10 is an initiator caspase in death receptor signaling.

S100A1: A regulator of myocardial contractility

Cubilin dysfunction causes abnormal metabolism of the steroid hormone 25(OH) vitamin D(3).

Adeno-associated virus vector-mediated IL-10 gene delivery prevents type 1 diabetes in NOD mice.

Plasma membrane rafts play a critical role in HIV-1 assembly and release.

Proteinase-activated receptor 2 is an anti-inflammatory signal for colonic lamina propria lymphocytes in a mouse model of colitis.

Selective blockade of T lymphocyte $K^{+}$ channels ameliorates experimental autoimmune encephalomyelitis, a model for multiple sclerosis

Inhibition of lung cancer cell growth and induction of apoptosis after reexpression of 3p21.3 candidate tumor suppressor gene SEMA3B.

Up-regulation of TNF-producing T cells in the bone marrow: a key mechanism by which estrogen deficiency induces bone loss in vivo.

The pattern of gene expression in human CD34(+) stem/progenitor cells.

Molecular basis for defective glycosylation and Pseudomonas pathogenesis in cystic fibrosis lung.

Identification of a developmental chemoattractant in Myxococcus xanthus through metabolic engineering.

Reafferent copies of imitated actions in the right superior temporal cortex.

Identification of neuropeptide-like protein gene families in Caenorhabditiselegans and other species.

Dynamic control of auditory activity during sleep: correlation between song response and EEG.

Activation of the epsilon isoform of protein kinase C in the mammalian nerve terminal.

Intrinsic near-24-h pacemaker period determines limits of circadian entrainment to a weak synchronizer in humans.

The synthetic enantiomer of pregnenolone sulfate is very active on memory in rats and mice, even more so than its physiological neurosteroid counterpart: distinct mechanisms?

Generation of the mu opioid receptor (MOR-1) protein by three new splice variants of the Oprm gene.

The dissociation of acetylcholine from open nicotinic receptor channels.

Syntrophin-dependent expression and localization of Aquaporin-4 water channel protein.

Identification of a neuronal nitric oxide synthase in isolated cardiac mitochondria using electrochemical detection.

Identification and characterization of a mitochondrial thioredoxin system in plants.

The DELLA motif is essential for gibberellin-induced degradation of RGA.

Chlorophyll b can serve as the major pigment in functional photosystem II complexes of cyanobacteria

Year: 2001 Volume: 98 Issue: 23

Year: 2001 Volume: 98 Issue: 22

Year: 2001 Volume: 98 Issue: 21

Year: 2001 Volume: 98 Issue: 20

Year: 2001 Volume: 98 Issue: 19

Year: 2001 Volume: 98 Issue: 18

Year: 2001 Volume: 98 Issue: 17

Year: 2001 Volume: 98 Issue: 16

Year: 2001 Volume: 98 Issue: 15

Year: 2001 Volume: 98 Issue: 14

Year: 2001 Volume: 98 Issue: 13

Year: 2001 Volume: 98 Issue: 12

Year: 2001 Volume: 98 Issue: 11

Year: 2001 Volume: 98 Issue: 10

Year: 2001 Volume: 98 Issue: 9

Year: 2001 Volume: 98 Issue: 8

Year: 2001 Volume: 98 Issue: 7

Year: 2001 Volume: 98 Issue: 6

Year: 2001 Volume: 98 Issue: 5

Year: 2001 Volume: 98 Issue: 4

Year: 2001 Volume: 98 Issue: 3

Year: 2001 Volume: 98 Issue: 2

Year: 2001 Volume: 98 Issue: 1

Year: 2000 Volume: 97

Year: 1999 Volume: 96

Year: 1998 Volume: 95

Year: 1997 Volume: 94

Year: 1996 Volume: 93

Year: 1995 Volume: 92

Year: 1994 Volume: 91

Year: 1993 Volume: 90

Year: 1992 Volume: 89

Year: 1991 Volume: 88

Year: 1990 Volume: 87

Year: 1989 Volume: 86

Year: 1988 Volume: 85

Year: 1987 Volume: 84

Year: 1986 Volume: 83

Year: 1985 Volume: 82

Year: 1984 Volume: 81

Year: 1983 Volume: 80

Year: 1982 Volume: 79

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

Variable deletion and duplication at recombination junction ends: implication for staggered double-strand cleavage in class-switch recombination.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kinoshita, K. Chen, X. Honjo, T.
Description	Author Affiliation: Chen X ( Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Yoshida Konoe-cho, Sakyo-ku Kyoto 606-8501, Japan.);
Abstract	Immunoglobulin class-switch recombination (CSR) gives rise to looped-out circular DNA of a cleaved S segment, which is lost eventually after cell divisions. To understand the molecular mechanism of S region cleavage during CSR, we constructed artificial CSR substrates in which inversion-type CSR takes place to retain the cleaved S segment. Sequencing analyses of recombinant clones of these substrates revealed that varying degrees of deletions and duplications exist at CSR breakpoints, suggesting the involvement of staggered cleavage of the S region in CSR. In addition, mutations frequently found near junctions showed a similar profile of base replacement to Ig somatic hypermutation. These findings suggest that single-strand tails of staggered cleavage may be repaired by error-prone DNA synthesis.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	24
Volume Number	98
Language	English
Publisher	National Academy of Sciences
Publisher Date	2001-11-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Gene Deletion Gene Duplication Genes, Immunoglobulin Immunoglobulin Class Switching Genetics Immunoglobulin Switch Region Immunoglobulin Mu-Chains Recombination, Genetic Animals Cell Line Chromosome Inversion DNA, Complementary Mice Molecular Sequence Data Nucleic Acid Conformation Point Mutation Sequence Analysis, DNA Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in