NDLI: Activation of CD1d-restricted T cells protects NOD mice from developing diabetes by regulating dendritic cell subsets.

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Activation of CD1d-restricted T cells protects NOD mice from developing diabetes by regulating dendritic cell subsets.

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Activation of CD1d-restricted T cells protects NOD mice from developing diabetes by regulating dendritic cell subsets.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Clare-salzer, M. Bahjat, K. S. Naumov, Y. N. Gausling, R. Strominger, J. L. Exley, M. A. Balk, S. B. Abraham, R. Koezuka, Y. Wilson, S. B.
Description	Author Affiliation: Naumov YN ( Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, MA 02115, USA.);
Abstract	CD1d-restricted invariant NKT (iNKT) cells are immunoregulatory cells whose loss exacerbates diabetes in nonobese diabetic (NOD) female mice. Here, we show that the relative numbers of iNKT cells from the pancreatic islets of NOD mice decrease at the time of conversion from peri-insulitis to invasive insulitis and diabetes. Conversely, NOD male mice who have a low incidence of diabetes showed an increased frequency of iNKT cells. Moreover, administration of alpha-galactosylceramide, a potent activating ligand presented by CD1d, ameliorated the development of diabetes in NOD female mice and resulted in the accumulation of iNKT cells and myeloid dendritic cells (DC) in pancreatic lymph nodes (PLN), but not in inguinal lymph nodes. Strikingly, injection of NOD female mice with myeloid DC isolated from the PLN, but not those from the inguinal lymph nodes, completely prevented diabetes. Thus, the immunoregulatory role of iNKT cells is manifested by the recruitment of tolerogenic myeloid DC to the PLN and the inhibition of ongoing autoimmune inflammation.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	24
Volume Number	98
Language	English
Publisher	National Academy of Sciences
Publisher Date	2001-11-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antigens, CD1 Immunology Dendritic Cells Diabetes Mellitus, Type 1 Killer Cells, Natural Lymphocyte Activation T-Lymphocytes Animals Antigens, CD1d Chemotaxis, Leukocyte Drug Effects Physiopathology Prevention & Control Disease Progression Galactosylceramides Pharmacology Islets Of Langerhans Cytology Lymph Nodes Mice Mice, Inbred NOD Pancreas Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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