NDLI: The 2.0-A crystal structure of tachylectin 5A provides evidence for the common origin of the innate immunity and the blood coagulation systems.

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The 2.0-A crystal structure of tachylectin 5A provides evidence for the common origin of the innate immunity and the blood coagulation systems.

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The 2.0-A crystal structure of tachylectin 5A provides evidence for the common origin of the innate immunity and the blood coagulation systems.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kairies, N. Bode, W. Muta, T. Fuentes-prior, P. Tsuda, R. Beisel, H. G. Kawabata, S. Iwanaga, S. Huber, R.
Description	Author Affiliation: Kairies N ( Max-Planck-Institut für Biochemie, Abteilung Strukturforschung, Am Klopferspitz 18a, 82152 Martinsried, Germany. kairies@biochem.mpg.de);
Abstract	Because invertebrates lack an adaptive immune system, they had to evolve effective intrinsic defense strategies against a variety of microbial pathogens. This ancient form of host defense, the innate immunity, is present in all multicellular organisms including humans. The innate immune system of the Japanese horseshoe crab Tachypleus tridentatus, serving as a model organism, includes a hemolymph coagulation system, which participates both in defense against microbes and in hemostasis. Early work on the evolution of vertebrate fibrinogen suggested a common origin of the arthropod hemolymph coagulation and the vertebrate blood coagulation systems. However, this conjecture could not be verified by comparing the structures of coagulogen, the clotting protein of the horseshoe crab, and of mammalian fibrinogen. Here we report the crystal structure of tachylectin 5A (TL5A), a nonself-recognizing lectin from the hemolymph plasma of T. tridentatus. TL5A shares not only a common fold but also related functional sites with the gamma fragment of mammalian fibrinogen. Our observations provide the first structural evidence of a common ancestor for the innate immunity and the blood coagulation systems.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	24
Volume Number	98
Language	English
Publisher	National Academy of Sciences
Publisher Date	2001-11-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Blood Coagulation Blood Proteins Chemistry Evolution, Molecular Lectins Amino Acid Sequence Animals Immunology Physiology Crystallography, X-Ray Fibrinogen Horseshoe Crabs Immunity, Innate Ligands Models, Molecular Molecular Sequence Data Protein Binding Protein Folding Protein Structure, Tertiary Sequence Homology, Amino Acid Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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