NDLI: Lipopolysaccharide-induced leptin release is neurally controlled.

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2003 Volume: 100

Year: 2002 Volume: 99

Year: 2001 Volume: 98

Year: 2001 Volume: 98 Issue: 26

Year: 2001 Volume: 98 Issue: 25

Genetic shift in photoperiodic response correlated with global warming.

The human salivary peptide histatin 5 exerts its antifungal activity through the formation of reactive oxygen species.

Global configuration of single titin molecules observed through chain-associated rhodamine dimers.

Spectroscopic studies of the vibrational and electronic properties of solid hydrogen to 285 GPa.

Cysteinyl-tRNA synthetase is not essential for viability of the archaeon Methanococcus maripaludis.

Differential roles of phosphorylation in the formation of transcriptional active RNA polymerase I.

Protein threading by learning.

A transcription factor regulatory circuit in differentiated pancreatic cells.

Structure of a quinohemoprotein amine dehydrogenase with an uncommon redox cofactor and highly unusual crosslinking.

Pulse confinement in optical fibers with random dispersion.

Mutation frequency and biological cost of antibiotic resistance in Helicobacter pylori.

Switch junction sequences in PMS2-deficient mice reveal a microhomology-mediated mechanism of Ig class switch recombination.

Induction of multiple signaling loops by MuSK during neuromuscular synapse formation.

Seven Wnt homologues in Drosophila: a case study of the developing tracheae.

RelE, a global inhibitor of translation, is activated during nutritional stress.

Conservative front tracking and level set algorithms.

Coexisting conformations of fibronectin in cell culture imaged using fluorescence resonance energy transfer.

Association between divergence and interspersed repeats in mammalian noncoding genomic DNA.

Import of amber and ochre suppressor tRNAs into mammalian cells: A general approach to site-specific insertion of amino acid analogues into proteins

Dynamic mechanisms of the membrane water channel aquaporin-1 (AQP1).

Underediting of glutamate receptor GluR-B mRNA in malignant gliomas.

IL-15 plays a major role in the persistence of Tax-specific CD8 cells in HAM/TSP patients.

Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy.

Translation of a nonpolyadenylated viral RNA is enhanced by binding of viral coat protein or polyadenylation of the RNA.

A high level of cyclooxygenase-2 inhibitor selectivity is associated with a reduced interference of platelet cyclooxygenase-1 inactivation by aspirin

Neurotrophins are key mediators of the myelination program in the peripheral nervous system.

Peripheral myelin protein 22 is a constituent of intercellular junctions in epithelia.

Meiotic recombination frequencies are affected by nutritional states in Saccharomycescerevisiae.

Signaling at the inhibitory natural killer cell immune synapse regulates lipid raft polarization but not class I MHC clustering.

Identification, characterization, and complete amino acid sequence of the conjugation-inducing glycoprotein (blepharmone) in the ciliate Blepharisma japonicum.

Critical involvement of a carbamylated lysine in catalytic function of class D beta-lactamases.

The anticancer drug-DNA complex: femtosecond primary dynamics for anthracycline antibiotics function.

Okazaki fragment processing: modulation of the strand displacement activity of DNA polymerase delta by the concerted action of replication protein A, proliferating cell nuclear antigen, and flap endonuclease-1.

Rapid shoreward encroachment of salt marsh cordgrass in response to accelerated sea-level rise.

A caged Ab reveals an immediate/instructive effect of BDNF during hippocampal synaptic potentiation.

The animal species-body size distribution of Marion Island.

Minocycline prevents nigrostriatal dopaminergic neurodegeneration in the MPTP model of Parkinson's disease.

Specificity in transmembrane helix-helix interactions can define a hierarchy of stability for sequence variants.

Detection of DNA point mutations and mRNA expression levels by rolling circle amplification in individual cells.

The KCl cotransporter isoform KCC3 can play an important role in cell growth regulation

The tumor autocrine motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum.

Histone tails modulate nucleosome mobility and regulate ATP-dependent nucleosome sliding by NURF

Genetically engineered macrophages expressing IFN-gamma restore alveolar immune function in scid mice.

Activation of the Mason-Pfizer monkey virus protease within immature capsids in vitro.

High frequency mitotic gene conversion in genetic hybrids of the oomycete Phytophthora sojae.

A quorum sensing-associated virulence gene of Pseudomonas aeruginosa encodes a LysR-like transcription regulator with a unique self-regulatory mechanism.

A vertebrate fatty acid desaturase with Delta 5 and Delta 6 activities.

A possible loophole in the theorem of Bell.

Bell's theorem and the problem of decidability between the views of Einstein and Bohr.

The nature of fluorescence emission in the red fluorescent protein DsRed, revealed by single-molecule detection.

Compressive nonlinearity in the hair bundle's active response to mechanical stimulation.

Comparison of a hair bundle's spontaneous oscillations with its response to mechanical stimulation reveals the underlying active process.

Identification of different emitting species in the red fluorescent protein DsRed by means of ensemble and single-molecule spectroscopy.

NMR structure reveals intramolecular regulation mechanism for pheromone binding and release.

Chlorophyllin intervention reduces aflatoxin-DNA adducts in individuals at high risk for liver cancer.

Lipopolysaccharide-induced leptin release is neurally controlled.

Role of SEREX-defined immunogenic wild-type cellular molecules in the development of tumor-specific immunity.

Dinosaurs, dragons, and dwarfs: the evolution of maximal body size.

Activation by GDNF of a transcriptional program repressing neurite growth in dorsal root ganglia.

Helicobacter pylori genetic diversity within the gastric niche of a single human host.

Function of GB1 and GB2 subunits in G protein coupling of $GABA_{B}$ receptors

Ligand-induced signal transduction within heterodimeric $GABA_{B}$ receptor

Enzyme-like proteins by computational design.

A transcriptional roadmap to wood formation.

Analysis of mitotic microtubule-associated proteins using mass spectrometry identifies astrin, a spindle-associated protein.

Plastome-encoded bacterial ribulose-1,5-bisphosphate carboxylase/oxygenase (RubisCO) supports photosynthesis and growth in tobacco

Complement activation in factor D-deficient mice.

Binding specificity of Escherichia coli trigger factor.

Candidate odorant receptors from the malaria vector mosquito Anopheles gambiae and evidence of down-regulation in response to blood feeding.

Targeting of human DNA polymerase iota to the replication machinery via interaction with PCNA.

Specific interference with gene expression induced by long, double-stranded RNA in mouse embryonal teratocarcinoma cell lines.

Flk-2 is a marker in hematopoietic stem cell differentiation: a simple method to isolate long-term stem cells.

Specific spatial learning deficits become severe with age in beta -amyloid precursor protein transgenic mice that harbor diffuse beta -amyloid deposits but do not form plaques.

Pattern formation in Escherichia coli: a model for the pole-to-pole oscillations of Min proteins and the localization of the division site.

Dimer formation drives the activation of the cell death protease caspase 9.

A second iron-regulatory system in yeast independent of Aft1p.

Fast dynamics of halophilic malate dehydrogenase and BSA measured by neutron scattering under various solvent conditions influencing protein stability

Radiation risk to low fluences of alpha particles may be greater than we thought.

Akt/PKB regulates laminin and collagen IV isotypes of the basement membrane.

The LIM domain gene LMO4 inhibits differentiation of mammary epithelial cells in vitro and is overexpressed in breast cancer.

Induction of platelet formation from megakaryocytoid cells by nitric oxide.

Bazooka is required for localization of determinants and controlling proliferation in the sensory organ precursor cell lineage in Drosophila.

Bazooka and atypical protein kinase C are required to regulate oocyte differentiation in the Drosophila ovary.

Three retrotransposon families in the genome of Giardia lamblia: two telomeric, one dead.

A likelihood ratio test for evolutionary rate shifts and functional divergence among proteins.

Restricted chromosomal silencing in nucleolar dominance.

T cell infiltration of the prostate induced by androgen withdrawal in patients with prostate cancer.

Two-step transcriptional amplification as a method for imaging reporter gene expression using weak promoters.

A tumor host range selection procedure identifies p150(sal2) as a target of polyoma virus large T antigen.

Mechanisms underlying rapid experience-dependent plasticity in the human visual cortex.

PTP and LTP at a hippocampal mossy fiber-interneuron synapse

Ricin A chain without its partner B chain is degraded after retrotranslocation from the endoplasmic reticulum to the cytosol in plant cells.

The ionic layer is required for efficient dissociation of the SNARE complex by alpha-SNAP and NSF.

Rapid formation of the stable tyrosyl radical in photosystem II

Year: 2001 Volume: 98 Issue: 24

Year: 2001 Volume: 98 Issue: 23

Year: 2001 Volume: 98 Issue: 22

Year: 2001 Volume: 98 Issue: 21

Year: 2001 Volume: 98 Issue: 20

Year: 2001 Volume: 98 Issue: 19

Year: 2001 Volume: 98 Issue: 18

Year: 2001 Volume: 98 Issue: 17

Year: 2001 Volume: 98 Issue: 16

Year: 2001 Volume: 98 Issue: 15

Year: 2001 Volume: 98 Issue: 14

Year: 2001 Volume: 98 Issue: 13

Year: 2001 Volume: 98 Issue: 12

Year: 2001 Volume: 98 Issue: 11

Year: 2001 Volume: 98 Issue: 10

Year: 2001 Volume: 98 Issue: 9

Year: 2001 Volume: 98 Issue: 8

Year: 2001 Volume: 98 Issue: 7

Year: 2001 Volume: 98 Issue: 6

Year: 2001 Volume: 98 Issue: 5

Year: 2001 Volume: 98 Issue: 4

Year: 2001 Volume: 98 Issue: 3

Year: 2001 Volume: 98 Issue: 2

Year: 2001 Volume: 98 Issue: 1

Year: 2000 Volume: 97

Year: 1999 Volume: 96

Year: 1998 Volume: 95

Year: 1997 Volume: 94

Year: 1996 Volume: 93

Year: 1995 Volume: 92

Year: 1994 Volume: 91

Year: 1993 Volume: 90

Year: 1992 Volume: 89

Year: 1991 Volume: 88

Year: 1990 Volume: 87

Year: 1989 Volume: 86

Year: 1988 Volume: 85

Year: 1987 Volume: 84

Year: 1986 Volume: 83

Year: 1985 Volume: 82

Year: 1984 Volume: 81

Year: 1983 Volume: 80

Year: 1982 Volume: 79

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

Lipopolysaccharide-induced leptin release is neurally controlled.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Mccann, S. M. Mastronardi, C. A. Dees, W. L. Srivastava, V. K. Yu, W. H.
Description	Author Affiliation: Mastronardi CA ( Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge, LA 70808-4124, USA.);
Abstract	Our hypothesis is that leptin release is controlled neurohormonally. Conscious, male rats bearing indwelling, external, jugular catheters were injected with the test drug or 0.9% NaCl (saline), and blood samples were drawn thereafter to measure plasma leptin. Anesthesia decreased plasma leptin concentrations within 10 min to a minimum at 120 min, followed by a rebound at 360 min. Administration (i.v.) of lipopolysaccharide (LPS) increased plasma leptin to almost twice baseline by 120 min, and it remained on a plateau for 360 min, accompanied by increased adipocyte leptin mRNA. Anesthesia largely blunted the LPS-induced leptin release at 120 min. Isoproterenol (beta-adrenergic agonist) failed to alter plasma leptin but reduced LPS-induced leptin release significantly. Propranolol (beta-receptor antagonist) produced a significant increase in plasma leptin but had no effect on the response to LPS. Phentolamine (alpha-adrenergic receptor blocker) not only increased plasma leptin (P < 0.001), but also augmented the LPS-induced increase (P < 0.001). alpha-Bromoergocryptine (dopaminergic-2 receptor agonist) decreased plasma leptin (P < 0.01) and blunted the LPS-induced rise in plasma leptin release (P < 0.001). We conclude that leptin is at least in part controlled neurally because anesthesia decreased plasma leptin and blocked its response to LPS. The findings that phentolamine and propranolol increased plasma leptin concentrations suggest that leptin release is inhibited by the sympathetic nervous system mediated principally by alpha-adrenergic receptors because phentolamine, but not propranolol, augmented the response to LPS. Because alpha-bromoergocryptine decreased basal and LPS-induced leptin release, dopaminergic neurons may inhibit basal and LPS-induced leptin release by suppression of release of prolactin from the adenohypophysis.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	25
Volume Number	98
Language	English
Publisher	National Academy of Sciences
Publisher Date	2001-12-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Leptin Secretion Lipopolysaccharides Toxicity Neurosecretory Systems Drug Effects Physiology Adipocytes Metabolism Adrenergic Alpha-Antagonists Pharmacology Adrenergic Beta-Agonists Adrenergic Beta-Antagonists Anesthesia Animals Bromocriptine Dopamine Agonists Isoproterenol Blood Genetics Models, Neurological Phentolamine Propranolol RNA, Messenger Sympathetic Nervous System Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in