NDLI: Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy.

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Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy.

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Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Gomes, M. D. Lecker, S. H. Jagoe, R. T. Navon, A. Goldberg, A. L.
Description	Author Affiliation: Gomes MD ( Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA.);
Abstract	Muscle wasting is a debilitating consequence of fasting, inactivity, cancer, and other systemic diseases that results primarily from accelerated protein degradation by the ubiquitin-proteasome pathway. To identify key factors in this process, we have used cDNA microarrays to compare normal and atrophying muscles and found a unique gene fragment that is induced more than ninefold in muscles of fasted mice. We cloned this gene, which is expressed specifically in striated muscles. Because this mRNA also markedly increases in muscles atrophying because of diabetes, cancer, and renal failure, we named it atrogin-1. It contains a functional F-box domain that binds to Skp1 and thereby to Roc1 and Cul1, the other components of SCF-type Ub-protein ligases (E3s), as well as a nuclear localization sequence and PDZ-binding domain. On fasting, atrogin-1 mRNA levels increase specifically in skeletal muscle and before atrophy occurs. Atrogin-1 is one of the few examples of an F-box protein or Ub-protein ligase (E3) expressed in a tissue-specific manner and appears to be a critical component in the enhanced proteolysis leading to muscle atrophy in diverse diseases.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	25
Volume Number	98
Language	English
Publisher	National Academy of Sciences
Publisher Date	2001-12-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Ligases Genetics Muscle Proteins Muscular Atrophy SKP Cullin F-Box Protein Ligases Amino Acid Sequence Animals Cloning, Molecular DNA, Complementary Fasting Metabolism Gene Expression Mice Mice, Inbred C57BL Molecular Sequence Data Etiology Oligonucleotide Array Sequence Analysis RNA, Messenger Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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