NDLI: Comparative genomic analysis of Vibrio cholerae: Genes that correlate with cholera endemic and pandemic disease

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Comparative genomic analysis of Vibrio cholerae: Genes that correlate with cholera endemic and pandemic disease

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Comparative genomic analysis of Vibrio cholerae: Genes that correlate with cholera endemic and pandemic disease

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Mekalanos, John J. Heidelberg, John F. Dziejman, Michelle Balon, Emmy Boyd, Dana Fraser, Clare M.
Description	Author Affiliation: Dziejman M ( Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA.);
Abstract	Historically, the first six recorded cholera pandemics occurred between 1817 and 1923 and were caused by Vibrio cholerae O1 serogroup strains of the classical biotype. Although strains of the El Tor biotype caused sporadic infections and cholera epidemics as early as 1910, it was not until 1961 that this biotype emerged to cause the 7th pandemic, eventually resulting in the global elimination of classical biotype strains as a cause of disease. The completed genome sequence of 7th pandemic El Tor O1 strain N16961 has provided an important tool to begin addressing questions about the evolution of V. cholerae as a human pathogen and environmental organism. To facilitate such studies, we constructed a V. cholerae genomic microarray that displays over 93% of the predicted genes of strain N16961 as spotted features. Hybridization of labeled genomic DNA from different strains to this microarray allowed us to compare the gene content of N16961 to that of other V. cholerae isolates. Surprisingly, the results reveal a high degree of conservation among the strains tested. However, genes unique to all pandemic strains as well as genes specific to 7th pandemic El Tor and related O139 serogroup strains were identified. These latter genes may encode gain-of-function traits specifically associated with displacement of the preexisting classical strains in South Asia and may also promote the establishment of endemic disease in previously cholera-free locations.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	3
Volume Number	99
Language	English
Publisher	National Academy of Sciences
Publisher Date	2002-02-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Cholera Epidemiology Genome, Bacterial Vibrio Cholerae Genetics Genes, Bacterial Genomics Oligonucleotide Array Sequence Analysis Polymerase Chain Reaction Serotyping Classification Isolation & Purification Comparative Study Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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