NDLI: Altered accumbens neural response to prediction of reward associated with place in dopamine D2 receptor knockout mice.

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Altered accumbens neural response to prediction of reward associated with place in dopamine D2 receptor knockout mice.

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Altered accumbens neural response to prediction of reward associated with place in dopamine D2 receptor knockout mice.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Tran, Anh Hai Uwano, Teruko Tamura, Ryoi Kobayashi, Tsuneyuki Matsumoto, Gen Katsuki, Motoya Ono, Taketoshi
Description	Author Affiliation: Tran AH ( Department of Physiology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Toyama 930-0194, Japan.);
Abstract	Midbrain dopaminergic activity seems to be important in forming the prediction of future events such as rewards. The nucleus accumbens (NAc) plays an important role in the integration of reward with motor function, and it receives dense dopamine innervation and extensive limbic and cortical afferents. Here, we examined the specific role of the dopamine D2 receptor (D2R) in mediating associative learning, locomotor activity, and regulating NAc neural responses by using D2R-knockout (KO) mice and their wild-type littermates. D2R-KO mice displayed reduced locomotor activity and slower acquisition of a place-learning task. D2R-KO eliminated the prereward inhibitory response of neurons in the NAc. In contrast, an increased number of neurons in D2R-KO mice displayed place-related activity. These results provide evidence that D2R in the NAc participates in coding for a specific type of neural response to incentive contingencies and partly in spatial learning.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	13
Volume Number	99
Language	English
Publisher	National Academy of Sciences
Publisher Date	2002-06-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Nucleus Accumbens Physiology Receptors, Dopamine D2 Animals Behavior, Animal Mice Mice, Knockout Genetics Comparative Study Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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