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A role for ASIC3 in the modulation of high-intensity pain stimuli.

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A role for ASIC3 in the modulation of high-intensity pain stimuli.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Chen, Chih-cheng Brownstein, Michael J. Zimmer, Anne Sun, Wei-hsin Hall, Jennifer Zimmer, Andreas
Description	Author Affiliation: Chen CC ( Laboratory of Genetics, National Institute of Mental Health, 36 Convent Drive 3D06, Bethesda, MD 20892, USA.);
Abstract	Acid-sensing ion channel 3 (ASIC3), a proton-gated ion channel of the degenerins/epithelial sodium channel (DEG/ENaC) receptor family is expressed predominantly in sensory neurons including nociceptive neurons responding to protons. To study the role of ASIC3 in pain signaling, we generated ASIC3 knockout mice. Mutant animals were healthy and responded normally to most sensory stimuli. However, in behavioral assays for pain responses, ASIC3 null mutant mice displayed a reduced latency to the onset of pain responses, or more pain-related behaviors, when stimuli of moderate to high intensity were used. This unexpected effect seemed independent of the modality of the stimulus and was observed in the acetic acid-induced writhing test (0.6 vs. 0.1-0.5%), in the hot-plate test (52.5 and 55 vs. 50 degrees C), and in tests for mechanically induced pain (tail-pinch vs. von Frey filaments). We postulate that ASIC3 is involved in modulating moderate- to high-intensity pain sensation.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	13
Volume Number	99
Language	English
Publisher	National Academy of Sciences
Publisher Date	2002-06-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Membrane Proteins Nerve Tissue Proteins Pain Physiopathology Physical Stimulation Sodium Channels Physiology Acid Sensing Ion Channels Animals Behavior, Animal DNA Primers Mice Mice, Knockout Genetics Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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