NDLI: Differentiation, cell fusion, and nuclear fusion during ex vivo repair of epithelium by human adult stem cells from bone marrow stroma.

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Differentiation, cell fusion, and nuclear fusion during ex vivo repair of epithelium by human adult stem cells from bone marrow stroma.

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Differentiation, cell fusion, and nuclear fusion during ex vivo repair of epithelium by human adult stem cells from bone marrow stroma.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Perry, Anthony Olson, Scott D. Ylostalo, Joni Wang, Meng Yu Smith, Jason Lynch, Patrick J. Spees, Jeffrey L. Prockop, Darwin J. Peister, Alexandra
Description	Author Affiliation: Spees JL ( Center for Gene Therapy, Tulane Health Sciences Center, New Orleans, LA 70112, USA.);
Abstract	To investigate stem cell differentiation in response to tissue injury, human mesenchymal stem cells (hMSCs) were cocultured with heat-shocked small airway epithelial cells. A subset of the hMSCs rapidly differentiated into epithelium-like cells, and they restored the epithelial monolayer. Immunocytochemistry and microarray analyses demonstrated that the cells expressed many genes characteristic of normal small airway epithelial cells. Some hMSCs differentiated directly after incorporation into the epithelial monolayer but other hMSCs fused with epithelial cells. Surprisingly, cell fusion was a frequent rather than rare event, in that up to 1% of the hMSCs added to the coculture system were recovered as binucleated cells expressing an epithelial surface epitope. Some of the fused cells also underwent nuclear fusion.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	5
Volume Number	100
Language	English
Publisher	National Academy of Sciences
Publisher Date	2003-03-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Bone Marrow Cells Cytology Cell Nucleus Metabolism Epithelial Cells Epithelium Membrane Glycoproteins Stem Cells Animals Antigens, CD Biosynthesis Antigens, CD24 Cell Differentiation Cells, Cultured Coculture Techniques Epitopes Chemistry Green Fluorescent Proteins Immunoblotting Immunohistochemistry In Situ Hybridization, Fluorescence Luminescent Proteins Mesoderm Oligonucleotide Array Sequence Analysis RNA Recombinant Fusion Proteins Time Factors Ultraviolet Rays Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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