NDLI: Control of neurotransmitter release by an internal gel matrix in synaptic vesicles.

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Control of neurotransmitter release by an internal gel matrix in synaptic vesicles.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Gómez De Aranda, Inmaculada Vilarrasa, Jaume Marsal, Jordi Blasi, Joan Reigada, David Pineda, Oriol Díez-pérez, Ismael Aleu, Jordi Gorostiza, Pau Verdaguer, Albert Solsona, Carles
Description	Author Affiliation: Reigada D ( Laboratory of Cellular and Molecular Neurobiology, Department of Cell Biology and Pathology, Medical School, Bellvitge Hospital, University of Barcelona-Campus of Bellvitge, Hospitalet de Llobregat, E-08907 Barcelona, Spain.);
Abstract	Neurotransmitters are stored in synaptic vesicles, where they have been assumed to be in free solution. Here we report that in Torpedo synaptic vesicles, only 5% of the total acetylcholine (ACh) or ATP content is free, and that the rest is adsorbed to an intravesicular proteoglycan matrix. This matrix, which controls ACh and ATP release by an ion-exchange mechanism, behaves like a smart gel. That is, it releases neurotransmitter and changes its volume when challenged with small ionic concentration change. Immunodetection analysis revealed that the synaptic vesicle proteoglycan SV2 is the core of the intravesicular matrix and is responsible for immobilization and release of ACh and ATP. We suggest that in the early steps of vesicle fusion, this internal matrix regulates the availability of free diffusible ACh and ATP, and thus serves to modulate the quantity of transmitter released.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	6
Volume Number	100
Language	English
Publisher	National Academy of Sciences
Publisher Date	2003-03-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Neurotransmitter Agents Secretion Synaptic Vesicles Acetylcholine Chemistry Adenosine Triphosphate Animals Electric Organ Gels In Vitro Techniques Microscopy, Atomic Force Models, Molecular Permeability Torpedo Physiology Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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