NDLI: A secreted high-affinity inhibitor of human TNF from Tanapox virus.

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2003 Volume: 100

Year: 2003 Volume: 100 Issue: 26

Year: 2003 Volume: 100 Issue: 25

Year: 2003 Volume: 100 Issue: 24

Year: 2003 Volume: 100 Issue: 23

Year: 2003 Volume: 100 Issue: 22

Year: 2003 Volume: 100 Issue: 21

Year: 2003 Volume: 100 Issue: 20

Year: 2003 Volume: 100 Issue: 19

Year: 2003 Volume: 100 Issue: 18

Year: 2003 Volume: 100 Issue: 17

Year: 2003 Volume: 100 Issue: 16

Year: 2003 Volume: 100 Issue: 15

Year: 2003 Volume: 100 Issue: 14

Year: 2003 Volume: 100 Issue: 13

Year: 2003 Volume: 100 Issue: 12

Year: 2003 Volume: 100 Issue: 11

Year: 2003 Volume: 100 Issue: 10

Year: 2003 Volume: 100 Issue: 9

Year: 2003 Volume: 100 Issue: 8

Genetic architecture and evolutionary constraint when the environment contains genes.

mRNA of placental origin is readily detectable in maternal plasma.

Translational control of inducible nitric oxide synthase expression by arginine can explain the arginine paradox.

Membrane potential fluorescence: a rapid and highly sensitive assay for nicotinic receptor channel function.

Probing polymerization forces by using actin-propelled lipid vesicles.

Stability of magnesiowustite in Earth's lower mantle.

Recombinant human erythropoietin protects the myocardium from ischemia-reperfusion injury and promotes beneficial remodeling.

The melanocortin-1 receptor gene mediates female-specific mechanisms of analgesia in mice and humans.

Mammalian Erv46 localizes to the endoplasmic reticulum-Golgi intermediate compartment and to cis-Golgi cisternae.

Induced nucleotide specificity in a GTPase.

Genes duplicated by polyploidy show unequal contributions to the transcriptome and organ-specific reciprocal silencing.

Herpes simplex virus 1 activates cdc2 to recruit topoisomerase II alpha for post-DNA synthesis expression of late genes.

Smooth muscle cells in human coronary atherosclerosis can originate from cells administered at marrow transplantation.

A GTP-driven motor moves proteins across the outer envelope of chloroplasts.

Circadian phase-specific degradation of the F-box protein ZTL is mediated by the proteasome.

alpha-Synuclein maps to a quantitative trait locus for alcohol preference and is differentially expressed in alcohol-preferring and -nonpreferring rats.

Epstein-Barr virus-infected B cells expanding in germinal centers of infectious mononucleosis patients do not participate in the germinal center reaction.

Regulation of myotubularin-related (MTMR)2 phosphatidylinositol phosphatase by MTMR5, a catalytically inactive phosphatase.

Therapeutic vaccine for acute and chronic motor neuron diseases: implications for amyotrophic lateral sclerosis.

Structure and assembly of an augmented Sm-like archaeal protein 14-mer

Chemical synaptic activity modulates nearby electrical synapses.

Timing of neural responses in cortical organotypic slices.

Enhanced protein domain discovery by using language modeling techniques from speech recognition.

Dichloroacetate effects on glucose and lactate oxidation by neurons and astroglia in vitro and on glucose utilization by brain in vivo

Structure of the GAT domain of human GGA1: a syntaxin amino-terminal domain fold in an endosomal trafficking adaptor.

Combinatorial modification of multiple lignin traits in trees through multigene cotransformation.

Stabilization of beta-catenin by a Wnt-independent mechanism regulates cardiomyocyte growth.

Gatm, a creatine synthesis enzyme, is imprinted in mouse placenta.

On conformally invariant differential operators in odd dimensions.

A reexamination of human-induced environmental change within the Lake Pátzcuaro Basin, Michoacán, Mexico.

Low T cell receptor expression and thermal fluctuations contribute to formation of dynamic multifocal synapses in thymocytes.

Frequency domain analysis of noise in autoregulated gene circuits.

Protein trans-splicing in transgenic plant chloroplast: reconstruction of herbicide resistance from split genes.

Site-specific contributions to the pH dependence of protein stability.

Engineering the proteolytic specificity of activated protein C improves its pharmacological properties.

IL-15R alpha expression on CD8+ T cells is dispensable for T cell memory.

Treatment with isotretinoin inhibits lipofuscin accumulation in a mouse model of recessive Stargardt's macular degeneration.

Comprehensive sampling of gene expression in human cell lines with massively parallel signature sequencing.

Microfluidics without microfabrication.

3 beta-acetoxyandrost-1,5-diene-17-ethylene ketal functions as a potent antiandrogen with marginal agonist activity.

Inhibition of calcineurin facilitates the induction of memory for sensitization in Aplysia: requirement of mitogen-activated protein kinase.

The endomembrane requirement for cell surface repair.

Drosophila p53 preserves genomic stability by regulating cell death.

Localization of denaturation bubbles in random DNA sequences.

Phosphorylation of $p47^{phox}$ directs phox homology domain from SH3 domain toward phosphoinositides, leading to phagocyte NADPH oxidase activation

Erythrocyte-binding antigen 175 mediates invasion in Plasmodium falciparum utilizing sialic acid-dependent and -independent pathways.

Solution structure of a functionally active fragment of decay-accelerating factor.

Processing, localization, and requirement of human separase for normal anaphase progression.

T cell leukemia I oncogene expression depends on the presence of Epstein-Barr virus in the virus-carrying Burkitt lymphoma lines.

Neural, not gonadal, origin of brain sex differences in a gynandromorphic finch.

New consumers: The influence of affluence on the environment

Conducting nanowires built by controlled self-assembly of amyloid fibers and selective metal deposition.

Predicting the practice effects on the blood oxygenation level-dependent (BOLD) function of fMRI in a symbolic manipulation task.

Majority of divergence between closely related DNA samples is due to indels.

Restoration of blood flow by using continuous perimuscular infiltration of plasmid DNA encoding subterranean mole rat Spalax ehrenbergi VEGF.

Striking variation in the sex ratio of pups born to mice according to whether maternal diet is high in fat or carbohydrate.

Bioinformatic design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein kinase A anchoring.

Endothelial nitric oxide synthase overexpression attenuates congestive heart failure in mice.

High-fidelity in vivo replication of DNA base shape mimics without Watson-Crick hydrogen bonds.

Hyaluronidase 2 negatively regulates RON receptor tyrosine kinase and mediates transformation of epithelial cells by jaagsiekte sheep retrovirus.

New components of the honey bee (Apis mellifera L.) queen retinue pheromone.

Closing the loop: the PmrA/PmrB two-component system negatively controls expression of its posttranscriptional activator PmrD.

Signal sequence within Fc gamma RIIA controls calcium wave propagation patterns: apparent role in phagolysosome fusion.

L-SIGN (CD 209L) is a liver-specific capture receptor for hepatitis C virus.

Identification of Down's syndrome critical locus gene SIM2-s as a drug therapy target for solid tumors.

C-terminal-binding protein corepresses epithelial and proapoptotic gene expression programs.

Retention of NMDA receptor NR2 subunits in the lumen of endoplasmic reticulum in targeted NR1 knockout mice.

An empty Drosophila stem cell niche reactivates the proliferation of ectopic cells.

Positive selection in the egg receptor for abalone sperm lysin.

A secreted high-affinity inhibitor of human TNF from Tanapox virus.

Evidence for direct carotenoid involvement in the regulation of photosynthetic light harvesting.

Early light-induced proteins protect Arabidopsis from photooxidative stress.

Assessing experimentally derived interactions in a small world.

Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation.

Expression profiling reveals altered satellite cell numbers and glycolytic enzyme transcription in nemaline myopathy muscle

Buffed energy landscapes: another solution to the kinetic paradoxes of protein folding.

The G protein-coupled receptor repertoires of human and mouse.

Isolation and identification of short nucleotide sequences that affect translation initiation in Saccharomyces cerevisiae.

Prenatal exposure to a cannabinoid agonist produces memory deficits linked to dysfunction in hippocampal long-term potentiation and glutamate release

Isothermal reactions for the amplification of oligonucleotides.

Evidence that the retroviral DNA integration process triggers an ATR-dependent DNA damage response.

Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions.

Amino acids determining enzyme-substrate specificity in prokaryotic and eukaryotic protein kinases.

Therapy for macular degeneration: insights from acne.

Evolution in a genetically heritable social environment.

Radar breaks the fog: insights into dorsoventral patterning in zebrafish.

How to interpret an ancient landscape.

Plasma membrane localization and function of the estrogen receptor alpha variant (ER46) in human endothelial cells.

What happens to genes in duplicated genomes.

Biologic activity of cytotoxic T lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients.

Placental mRNA in maternal plasma: prospects for fetal screening.

A silent bomb: the risk of anthrax as a weapon of mass destruction.

Filamin-A fragment localizes to the nucleus to regulate androgen receptor and coactivator functions.

Human tumstatin and human endostatin exhibit distinct antiangiogenic activities mediated by αvβ3 and α5β1 integrins

Inhibition of plaque neovascularization reduces macrophage accumulation and progression of advanced atherosclerosis.

Peptide-mediated broad-spectrum plant resistance to tospoviruses.

Epigenetic abnormalities associated with a chromosome 18(q21-q22) inversion and a Gilles de la Tourette syndrome phenotype.

A complex microbiota from snowball Earth times: microfossils from the Neoproterozoic Kingston Peak Formation, Death Valley, USA.

Essential Bacillus subtilis genes.

The high variance of AMPA receptor- and NMDA receptor-mediated responses at single hippocampal synapses: Evidence for multiquantal release

Role of SeqA and Dam in Escherichia coli gene expression: a global/microarray analysis.

MAN1 and emerin have overlapping function(s) essential for chromosome segregation and cell division in Caenorhabditis elegans.

Bacterial volatiles promote growth in Arabidopsis.

The cyclopentenone 15-deoxy-delta 12,14-prostaglandin J2 binds to and activates H-Ras.

The hydration structure of guanidinium and thiocyanate ions: implications for protein stability in aqueous solution.

Heterogeneous clearance rates of long-lived lymphocytes infected with HIV: intrinsic stability predicts lifelong persistence.

A network of rice genes associated with stress response and seed development.

Assembly of high-affinity insulin receptor agonists and antagonists from peptide building blocks.

Abbreviated incubation times for human prions in mice expressing a chimeric mouse-human prion protein transgene.

Amyloid deposition in the hippocampus and entorhinal cortex: quantitative analysis of a transgenic mouse model.

Year: 2003 Volume: 100 Issue: 7

Year: 2003 Volume: 100 Issue: 6

Year: 2003 Volume: 100 Issue: 5

Year: 2003 Volume: 100 Issue: 4

Year: 2003 Volume: 100 Issue: 3

Year: 2003 Volume: 100 Issue: 2

Year: 2003 Volume: 100 Issue: Suppl 2

Year: 2003 Volume: 100 Issue: 1

Year: 2003 Volume: 100 Issue: Suppl 1

Year: 2002 Volume: 99

Year: 2001 Volume: 98

Year: 2000 Volume: 97

Year: 1999 Volume: 96

Year: 1998 Volume: 95

Year: 1997 Volume: 94

Year: 1996 Volume: 93

Year: 1995 Volume: 92

Year: 1994 Volume: 91

Year: 1993 Volume: 90

Year: 1992 Volume: 89

Year: 1991 Volume: 88

Year: 1990 Volume: 87

Year: 1989 Volume: 86

Year: 1988 Volume: 85

Year: 1987 Volume: 84

Year: 1986 Volume: 83

Year: 1985 Volume: 82

Year: 1984 Volume: 81

Year: 1983 Volume: 80

Year: 1982 Volume: 79

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

A secreted high-affinity inhibitor of human TNF from Tanapox virus.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Paulose-murphy, Mini Singh, Rajkumari Brunetti, Craig R. Mcfadden, Grant Barrett, John W. Essani, Karim Qin, Jing Schneider, Pascal Tardivel, Aubry
Description	Author Affiliation: Brunetti CR ( BioTherapeutics Group, Robarts Research Institute, 1400 Western Road, London, ON, Canada N6G 2V4.);
Abstract	A class of secreted poxvirus tumor necrosis factor (TNF)-binding proteins has been isolated from Tanapox-infected cell supernatants. The inhibitor bound to a TNF-affinity column and was identified as the product of the 2L gene. Sequence analysis of 2L family members from other yatapoxviruses and swinepox virus yielded no sequence homology to any known cellular gene. The expressed Tanapox virus 2L protein bound to human TNF with high affinity (K(d) = 43 pM) and exhibits an unusually slow off-rate. However, 2L is unable to bind to a wide range of human TNF family members. The 2L protein can inhibit human TNF from binding to TNF receptors I and II as well as block TNF-induced cytolysis. Thus, Tanapox virus 2L represents an inhibitor of human TNF and offers a unique strategy with which to modulate TNF activity.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	8
Volume Number	100
Language	English
Publisher	National Academy of Sciences
Publisher Date	2003-04-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Carrier Proteins Physiology Tumor Necrosis Factor-alpha Antagonists & Inhibitors Viral Proteins Yatapoxvirus Amino Acid Sequence Animals Antigens, CD Metabolism Genetics Pharmacology DNA, Viral Genes, Viral Mice Molecular Sequence Data Receptors, Tumor Necrosis Factor Receptors, Tumor Necrosis Factor, Type I Receptors, Tumor Necrosis Factor, Type II Recombinant Proteins Sequence Homology, Amino Acid Tumor Necrosis Factor Decoy Receptors Yaba Monkey Tumor Virus Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in