NDLI: C-terminal-binding protein corepresses epithelial and proapoptotic gene expression programs.

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C-terminal-binding protein corepresses epithelial and proapoptotic gene expression programs.

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C-terminal-binding protein corepresses epithelial and proapoptotic gene expression programs.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zhang, Qinghong Frisch, Steven M. Grooteclaes, Madeleine Deveraux, Quinn Hildebrand, Jeffrey Goodman, Richard H.
Description	Author Affiliation: Grooteclaes M ( The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.);
Abstract	The genesis of carcinoma cells often involves epithelial-to-mesenchymal transitions and the acquisition of apoptosis resistance, but it is unclear whether these alterations are controlled coordinately or independently. Our previously reported effects of adenovirus E1a in human tumor cells raised the possibility that the E1a-interacting corepressor protein C-terminal-binding protein (CtBP) might selectively repress epithelial cell adhesion and proapoptotic genes. Here, we report that CtBP-knockout cells were hypersensitive to apoptosis. Correspondingly, microarray analysis of CtBP-knockout vs. CtBP-rescued mouse embryo fibroblasts revealed that many epithelial-specific and proapoptotic genes were indeed regulated by CtBP. Neither the apoptosis nor the repression activities of CtBP required histidine-315, suggesting that the proposed dehydrogenase activity is not essential for CtBP function. The results presented herein establish two functional roles of CtBP: to corepress epithelial genes, thus permitting epithelial-to-mesenchymal transitions, and to modulate the cellular threshold for apoptotic responses.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	8
Volume Number	100
Language	English
Publisher	National Academy of Sciences
Publisher Date	2003-04-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Apoptosis Genetics DNA-Binding Proteins Metabolism Phosphoproteins Repressor Proteins Alcohol Oxidoreductases Animals Binding Sites Cell Line Deficiency Epithelial Cells Cytology Gene Expression In Vitro Techniques Mice Mice, Knockout Oxidoreductases Chemistry Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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