NDLI: Biomimetic organization: Octapeptide self-assembly into nanotubes of viral capsid-like dimension.

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Biomimetic organization: Octapeptide self-assembly into nanotubes of viral capsid-like dimension.

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Biomimetic organization: Octapeptide self-assembly into nanotubes of viral capsid-like dimension.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Artzner, Franck Paternostre, Maïté Gulik-krzywicki, Thaddée Narayanan, Theyencheri Keller, Gérard Dedieu, Jean-claude Torres, Maria-luisa Robert, Bruno Cherif-cheikh, Roland Calvo, Pilar Valéry, Céline
Description	Author Affiliation: Valéry C ( Unité Mixte de Recherche 8612, Centre National de la Recherche Scientifique, Faculté de Pharmacie, 5 Rue J.B. Clément, 92296 Châtenay-Malabry Cedex, France.);
Abstract	The controlled self-assembly of complex molecules into well defined hierarchical structures is a promising route for fabricating nanostructures. These nanoscale structures can be realized by naturally occurring proteins such as tobacco mosaic virus, capsid proteins, tubulin, actin, etc. Here, we report a simple alternative method based on self-assembling nanotubes formed by a synthetic therapeutic octapeptide, Lanreotide in water. We used a multidisciplinary approach involving optical and electron microscopies, vibrational spectroscopies, and small and wide angle x-ray scattering to elucidate the hierarchy of structures exhibited by this system. The results revealed the hexagonal packing of nanotubes, and high degree of monodispersity in the tube diameter (244 A) and wall thickness (approximately equal to 18 A). Moreover, the diameter is tunable by suitable modifications in the molecular structure. The self-assembly of the nanotubes occurs through the association of beta-sheets driven by amphiphilicity and a systematic aromatic/aliphatic side chain segregation. This original and simple system is a unique example for the study of complex self-assembling processes generated by de novo molecules or amyloid peptides.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	18
Volume Number	100
Language	English
Publisher	National Academy of Sciences
Publisher Date	2003-09-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Capsid Chemistry Peptides, Cyclic Somatostatin Analogs & Derivatives Biomimetics Models, Molecular Protein Conformation Protein Structure, Secondary Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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