NDLI: Fatty acid biosynthesis in Mycobacterium tuberculosis: lateral gene transfer, adaptive evolution, and gene duplication.

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Fatty acid biosynthesis in Mycobacterium tuberculosis: lateral gene transfer, adaptive evolution, and gene duplication.

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Fatty acid biosynthesis in Mycobacterium tuberculosis: lateral gene transfer, adaptive evolution, and gene duplication.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Fitzpatrick, David A. Mcinerney, James O. Kinsella, Rhoda J. Creevey, Christopher J.
Description	Author Affiliation: Kinsella RJ ( Bioinformatics and Pharmacogenomics Laboratory, Biology Department, National University of Ireland, Maynooth, County Kildare, Ireland.);
Abstract	Mycobacterium tuberculosis is a high GC Gram-positive member of the actinobacteria. The mycobacterial cell wall is composed of a complex assortment of lipids and is the interface between the bacterium and its environment. The biosynthesis of fatty acids plays an essential role in the formation of cell wall components, in particular mycolic acids, which have been targeted by many of the drugs used to treat M. tuberculosis infection. M. tuberculosis has approximately 250 genes involved in fatty acid metabolism, a much higher proportion than in any other organism. In silico methods have been used to compare the genome of M. tuberculosis CDC1551 to a database of 58 complete bacterial genomes. The resulting alignments were scanned for genes specifically involved in fatty acid biosynthetic pathway I. Phylogenetic analysis of these alignments was used to investigate horizontal gene transfer, gene duplication, and adaptive evolution. It was found that of the eight gene families examined, five of the phylogenies reconstructed suggest that the actinobacteria have a closer relationship with the alpha-proteobacteria than expected. This is either due to either an ancient transfer of genes or deep paralogy and subsequent retention of the genes in unrelated lineages. Additionally, adaptive evolution and gene duplication have been an influence in the evolution of the pathway. This study provides a key insight into how M. tuberculosis has developed its unique fatty acid synthetic abilities.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	18
Volume Number	100
Language	English
Publisher	National Academy of Sciences
Publisher Date	2003-09-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Fatty Acids Biosynthesis Gene Duplication Gene Transfer, Horizontal Mycobacterium Tuberculosis Genetics Metabolism Acetyl-CoA Carboxylase Adaptation, Physiological Biological Evolution Evolution, Molecular Classification Phylogeny Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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