NDLI: An ultrasensitive $Ca^{2+}/calmodulin-dependent$ protein kinase II-protein phosphatase 1 switch facilitates specificity in postsynaptic calcium signaling

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2003 Volume: 100

Year: 2003 Volume: 100 Issue: 26

Year: 2003 Volume: 100 Issue: 25

Year: 2003 Volume: 100 Issue: 24

Year: 2003 Volume: 100 Issue: 23

Year: 2003 Volume: 100 Issue: 22

Year: 2003 Volume: 100 Issue: 21

Year: 2003 Volume: 100 Issue: 20

Year: 2003 Volume: 100 Issue: 19

Year: 2003 Volume: 100 Issue: 18

Simultaneous analysis of phytohormones, phytotoxins, and volatile organic compounds in plants.

Osmotic water transport through carbon nanotube membranes.

In-stream uptake dampens effects of major forest disturbance on watershed nitrogen export.

Manganese activation of superoxide dismutase 2 in Saccharomyces cerevisiae requires MTM1, a member of the mitochondrial carrier family.

Genetic footprints of demographic expansion in North America, but not Amazonia, during the Late Quaternary.

Haplotype variation in bovine Toll-like receptor 4 and computational prediction of a positively selected ligand-binding domain.

gamma-Tubulin function during female germ-cell development and oogenesis in Drosophila.

Mpi recombinase globally modulates the surface architecture of a human commensal bacterium.

Rapamycin causes down-regulation of CCR5 and accumulation of anti-HIV beta-chemokines: an approach to suppress R5 strains of HIV-1.

Breast cancer classification and prognosis based on gene expression profiles from a population-based study.

Fatty acid biosynthesis in Mycobacterium tuberculosis: lateral gene transfer, adaptive evolution, and gene duplication.

A tenth atp gene and the conserved atpI gene of a Bacillus atp operon have a role in $Mg^{2+}$ uptake

DNA vaccine coding for the full-length infectious Kunjin virus RNA protects mice against the New York strain of West Nile virus

Activation of $CB_{2}$ cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: Pain inhibition by receptors not present in the CNS

B7x: a widely expressed B7 family member that inhibits T cell activation.

Group interest versus self-interest in smallpox vaccination policy.

Acetyl-CoA carboxylase 2 mutant mice are protected against obesity and diabetes induced by high-fat/high-carbohydrate diets.

Cuticular hydrocarbons mediate discrimination of reproductives and nonreproductives in the ant Myrmecia gulosa.

HILS1 is a spermatid-specific linker histone H1-like protein implicated in chromatin remodeling during mammalian spermiogenesis.

Estrogen deficiency induces bone loss by increasing T cell proliferation and lifespan through IFN-gamma-induced class II transactivator.

Niemann-Pick C heterozygosity confers resistance to lesional necrosis and macrophage apoptosis in murine atherosclerosis.

Honor thy symbionts.

Glutamate-binding affinity of Drosophila metabotropic glutamate receptor is modulated by association with lipid rafts.

Drosophila spalt/spalt-related mutants exhibit Townes-Brocks' syndrome phenotypes.

Evidence for a primary islet autoantigen (preproinsulin 1) for insulitis and diabetes in the nonobese diabetic mouse.

Alzheimer's disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss.

Participation of the S4 voltage sensor in the $Mg^{2+}-dependent$ activation of large conductance (BK) $K^{+}$ channels

Homez, a homeobox leucine zipper gene specific to the vertebrate lineage.

Estimating the distribution of fitness effects from DNA sequence data: implications for the molecular clock.

Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation.

Conjugative coupling proteins interact with cognate and heterologous VirB10-like proteins while exhibiting specificity for cognate relaxosomes.

A noncanonical sequence phosphorylated by casein kinase 1 in β-catenin may play a role in casein kinase 1 targeting of important signaling proteins

Effectiveness of diabetes mellitus screening recommendations.

Kaposi's sarcoma-associated herpesvirus-infected primary effusion lymphoma has a plasma cell gene expression profile.

Targeted disruption of GPR7, the endogenous receptor for neuropeptides B and W, leads to metabolic defects and adult-onset obesity.

Role and location of the unusual redox-active cysteines in the hydrophobic domain of the transmembrane electron transporter DsbD.

Divergent impact of progesterone and medroxyprogesterone acetate (Provera) on nuclear mitogen-activated protein kinase signaling.

Liquid-solid transition in nuclei of protein crystals.

Dielectrophoretic dynamic light-scattering (DDLS) spectroscopy.

An ultrasensitive $Ca^{2+}/calmodulin-dependent$ protein kinase II-protein phosphatase 1 switch facilitates specificity in postsynaptic calcium signaling

Self-assembly of synthetic peptides control conformation and optical properties of a zwitterionic polythiophene derivative.

The yeasts Rho1p and Pkc1p regulate the transport of chitin synthase III (Chs3p) from internal stores to the plasma membrane.

Intense myocyte formation from cardiac stem cells in human cardiac hypertrophy.

Gating currents associated with intramembrane charge displacement in HERG potassium channels

Synaptopodin-deficient mice lack a spine apparatus and show deficits in synaptic plasticity.

Chaperone-mediated in vitro assembly of Polyomavirus capsids.

Specific sequence changes in multiple transcript system DYT3 are associated with X-linked dystonia parkinsonism

A calmodulin-binding protein from Arabidopsis has an essential role in pollen germination.

Brain potentials associated with conscious aftereffects induced by unseen stimuli in a blindsight subject.

The complete genome sequence of the Arabidopsis and tomato pathogen Pseudomonas syringae pv. tomato DC3000.

Allopatric genetic origins for sympatric host-plant shifts and race formation in Rhagoletis.

Modulation of DNA damage-induced apoptosis by cell adhesion is independently mediated by p53 and c-Abl.

Reconstitution of recombination-dependent DNA synthesis in herpes simplex virus 1.

A mouse model of Rubinstein-Taybi syndrome: defective long-term memory is ameliorated by inhibitors of phosphodiesterase 4.

Hierarchical model of gene regulation by transforming growth factor beta.

Minocycline inhibits caspase-independent and -dependent mitochondrial cell death pathways in models of Huntington's disease.

Ian4 is required for mitochondrial integrity and T cell survival.

Short- and long-range effects of Sonic hedgehog in limb development.

Molecular imaging with endogenous substances.

Increase in signal-to-noise ratio of > 10,000 times in liquid-state NMR.

Wilderness and biodiversity conservation.

Biomimetic organization: Octapeptide self-assembly into nanotubes of viral capsid-like dimension.

The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA.

Stress promotes maleness in hermaphroditic modular animals.

Intermolecular thiol cross-linking via loops in the lactose permease of Escherichia coli.

Comparing the continuous representation of time-series expression profiles to identify differentially expressed genes.

Unsuspected role of the brain morphogenetic gene Otx1 in hematopoiesis.

S-adenosyl-L-methionine is an effector in the posttranscriptional autoregulation of the cystathionine gamma-synthase gene in Arabidopsis.

Expression deconvolution: a reinterpretation of DNA microarray data reveals dynamic changes in cell populations.

Can energy landscape roughness of proteins and RNA be measured by using mechanical unfolding experiments?

WNT7a induces E-cadherin in lung cancer cells.

ACE2 is required for daughter cell-specific G1 delay in Saccharomyces cerevisiae.

Hydrogen atoms in proteins: positions and dynamics.

Development of object concepts in infancy: Evidence for early learning in an eye-tracking paradigm.

Amphetamine or cocaine limits the ability of later experience to promote structural plasticity in the neocortex and nucleus accumbens.

Oxygen toxicity and the health and survival of eukaryote cells: a new piece is added to the puzzle.

Hormones are in the air.

A stream's role in watershed nutrient export.

The subtleties of water in small spaces.

Year: 2003 Volume: 100 Issue: 17

Year: 2003 Volume: 100 Issue: 16

Year: 2003 Volume: 100 Issue: 15

Year: 2003 Volume: 100 Issue: 14

Year: 2003 Volume: 100 Issue: 13

Year: 2003 Volume: 100 Issue: 12

Year: 2003 Volume: 100 Issue: 11

Year: 2003 Volume: 100 Issue: 10

Year: 2003 Volume: 100 Issue: 9

Year: 2003 Volume: 100 Issue: 8

Year: 2003 Volume: 100 Issue: 7

Year: 2003 Volume: 100 Issue: 6

Year: 2003 Volume: 100 Issue: 5

Year: 2003 Volume: 100 Issue: 4

Year: 2003 Volume: 100 Issue: 3

Year: 2003 Volume: 100 Issue: 2

Year: 2003 Volume: 100 Issue: Suppl 2

Year: 2003 Volume: 100 Issue: 1

Year: 2003 Volume: 100 Issue: Suppl 1

Year: 2002 Volume: 99

Year: 2001 Volume: 98

Year: 2000 Volume: 97

Year: 1999 Volume: 96

Year: 1998 Volume: 95

Year: 1997 Volume: 94

Year: 1996 Volume: 93

Year: 1995 Volume: 92

Year: 1994 Volume: 91

Year: 1993 Volume: 90

Year: 1992 Volume: 89

Year: 1991 Volume: 88

Year: 1990 Volume: 87

Year: 1989 Volume: 86

Year: 1988 Volume: 85

Year: 1987 Volume: 84

Year: 1986 Volume: 83

Year: 1985 Volume: 82

Year: 1984 Volume: 81

Year: 1983 Volume: 80

Year: 1982 Volume: 79

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

An ultrasensitive $Ca^{2+}/calmodulin-dependent$ protein kinase II-protein phosphatase 1 switch facilitates specificity in postsynaptic calcium signaling

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Schulman, Howard Meyer, Tobias Bradshaw, J. Michael Kubota, Yoshi
Description	Author Affiliation: Bradshaw JM ( Department of Neurobiology, Stanford University School of Medicine, Stanford, CA 94305, USA. michael.bradshaw@stanford.edu);
Abstract	The strength of hippocampal synapses can be persistently increased by signals that activate Ca2+/calmodulin-dependent protein kinase II (CaMKII). This CaMKII-dependent long-term potentiation is important for hippocampal learning and memory. In this work we show that CaMKII exhibits an intriguing switch-like activation that likely is important for changes in synaptic strength. We found that autophosphorylation of CaMKII by itself showed a steep dependence on Ca2+ concentration [Hill coefficient (nH) approximately 5]. However, an even steeper Ca2+ dependence (nH approximately 8) was observed when autophosphorylation is balanced by the dephosphorylation activity of protein phosphatase 1 (PP1). This autophosphorylation-dephosphorylation switch was found to be reversible because PP1 dephosphorylates CaMKII when Ca2+ is lowered to a basal level. The switch-like response of a CaMKII-PP1 system suggests that CaMKII and PP1 may function together as a simple molecular device that specifically translates only strong Ca2+ signals into all-or-none potentiation of individual hippocampal synapses.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	18
Volume Number	100
Language	English
Publisher	National Academy of Sciences
Publisher Date	2003-09-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Calcium Signaling Physiology Calcium-Calmodulin-Dependent Protein Kinases Phosphoprotein Phosphatases Synapses Calcium-Calmodulin-Dependent Protein Kinase Type 2 Hippocampus Phosphorylation Protein Phosphatase 1 Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in