NDLI: Analysis of an orf virus chemokine-binding protein: Shifting ligand specificities among a family of poxvirus viroceptors.

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Analysis of an orf virus chemokine-binding protein: Shifting ligand specificities among a family of poxvirus viroceptors.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Brunetti, Craig Seet, Bruce T. Mccaughan, Catherine A. Mcfadden, Grant Mercer, Andrew Handel, Tracy M. Fleming, Stephen B.
Description	Author Affiliation: Seet BT ( Department of Microbiology and Immunology, University of Western Ontario, London, ON, Canada N6A 5C1.);
Abstract	We identify a secreted chemokine inhibitor encoded by orf virus (ORFV), the prototypic poxvirus of the Parapoxvirus genus, and show that it is related to the poxvirus type II CC-chemokine-binding proteins (CBP-II) produced by members of the Orthopoxvirus and Leporipoxvirus genera. The ORFV chemokine-binding protein (CBP) is functionally similar to the CBP-II proteins in its ability to bind and inhibit many CC-chemokines with high affinity. However, unlike CBP-II, the ORFV CBP also binds with high affinity to lymphotactin, a member of the C-chemokine family, demonstrating that the ORFV CBP possesses an altered binding specificity. Interestingly, the amino acid sequence of ORFV CBP more closely resembles the granulocyte-macrophage colony-stimulating factor/IL-2 inhibitory factor also produced by ORFV, implicating the granulocyte-macrophage colony-stimulating factor/IL-2 inhibitory factor protein as a highly diverged, but related, member of the CBP-II protein family. Notably, these findings suggest that the genes that encode these proteins derive from a common poxvirus ancestral gene that has since been modified in binding specificity during speciation of the poxvirus genera. Overall, these findings illustrate the concept of evolution of viral proteins at the biophysical and molecular interface.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	25
Volume Number	100
Language	English
Publisher	National Academy of Sciences
Publisher Date	2003-12-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Chemokines Metabolism Orf Virus Amino Acid Sequence Calcium Cloning, Molecular Cytokines DNA Chemistry Epitopes Granulocyte-Macrophage Colony-Stimulating Factor Interleukin-2 Kinetics Leukocytes Ligands Models, Molecular Molecular Sequence Data Phylogeny Poxviridae Genetics Protein Binding Sequence Homology, Amino Acid Signal Transduction Time Factors Viral Proteins Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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