NDLI: Regulation of the human GLUT4 gene promoter: interaction between a transcriptional activator and myocyte enhancer factor 2A.

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2003 Volume: 100

Year: 2003 Volume: 100 Issue: 26

Year: 2003 Volume: 100 Issue: 25

Influenza virus hemagglutinin concentrates in lipid raft microdomains for efficient viral fusion.

Mouse glucocorticoid-induced tumor necrosis factor receptor ligand is costimulatory for T cells.

The base excision repair enzyme MED1 mediates DNA damage response to antitumor drugs and is associated with mismatch repair system integrity.

The thermodynamics of template-directed DNA synthesis: base insertion and extension enthalpies.

Darwinian natural selection for orange bioluminescent color in a Jamaican click beetle.

Natural scene statistics as the universal basis of color context effects.

Ethanol enhances alpha 4 beta 3 delta and alpha 6 beta 3 delta gamma-aminobutyric acid type A receptors at low concentrations known to affect humans.

Transfer of neutralizing IgG to macaques 6 h but not 24 h after SHIV infection confers sterilizing protection: implications for HIV-1 vaccine development.

Chromosomal site-specific double-strand breaks are efficiently targeted for repair by oligonucleotides in yeast.

Experimental test of predation's effect on divergent selection during character displacement in sticklebacks.

Fragile site orthologs FHIT/FRA3B and Fhit/Fra14A2: evolutionarily conserved but highly recombinogenic.

Distinct and nonoverlapping roles for pRB and cyclin D:cyclin-dependent kinases 4/6 activity in melanocyte survival.

Regulation of the human GLUT4 gene promoter: interaction between a transcriptional activator and myocyte enhancer factor 2A.

The timing of phasic transmitter release is $Ca^{2+}-dependent$ and lacks a direct influence of presynaptic membrane potential

Apical recycling systems regulate directional budding of respiratory syncytial virus from polarized epithelial cells.

A peptide switch regulates DNA polymerase processivity.

Biologically active fragment of a human tRNA synthetase inhibits fluid shear stress-activated responses of endothelial cells.

Turning immunological memory into amnesia by depletion of dividing T cells.

TRF3, a TATA-box-binding protein-related factor, is vertebrate-specific and widely expressed.

TRPM5 is a transient $Ca^{2+}-activated$ cation channel responding to rapid changes in $[Ca^{2+}]_{i}$

Frap, FKBP12 rapamycin-associated protein, is a candidate gene for the plasmacytoma resistance locus Pctr2 and can act as a tumor suppressor gene

DNA bending and unbending by MutS govern mismatch recognition and specificity.

Hematopoietic progenitors express neural genes.

The RNA polymerase III transcriptome revealed by genome-wide localization and activity-occupancy relationships.

P53 hot-spot mutants are resistant to ubiquitin-independent degradation by increased binding to NAD(P)H:quinone oxidoreductase 1.

Genetic engineering of the glyoxalase pathway in tobacco leads to enhanced salinity tolerance

Contribution of astrocytes to hippocampal long-term potentiation through release of D-serine.

A microfluidic model for single-cell capillary obstruction by Plasmodium falciparum-infected erythrocytes.

Adhesive-cohesive model for protein compressibility: an alternative perspective on stability.

Interpulse growth hormone secretion in the episodic plasma profile causes the sex reversal of cytochrome P450s in senescent male rats.

Food-web constraints on biodiversity-ecosystem functioning relationships.

Atomically detailed folding simulation of the B domain of staphylococcal protein A from random structures.

Reduction of lipocalin-type prostaglandin D synthase in the preoptic area of female mice mimics estradiol effects on arousal and sex behavior.

Hox cluster duplications and the opportunity for evolutionary novelties.

Evolution of genomic diversity and sex at extreme environments: fungal life under hypersaline Dead Sea stress.

Cancerous stem cells can arise from pediatric brain tumors.

Concerted regulation of skeletal muscle contractility by oxygen tension and endogenous nitric oxide

Requirement of p53 targets in chemosensitization of colonic carcinoma to death ligand therapy.

Differential G protein-coupled cannabinoid receptor signaling by anandamide directs blastocyst activation for implantation

Activity of a type 1 picornavirus internal ribosomal entry site is determined by sequences within the 3' nontranslated region.

Mucosal tolerance to E-selectin provides cell-mediated protection against ischemic brain injury.

From the Cover: Segmented spiral waves in a reaction-diffusion system.

Imaging Tetrahymena ribozyme splicing activity in single live mammalian cells.

An adenoviral vector cancer vaccine that delivers a tumor-associated antigen/CD40-ligand fusion protein to dendritic cells.

Natural occurrence and synthesis of two new postspinel polymorphs of chromite.

Natural killer cells in HIV-1 infection: dichotomous effects of viremia on inhibitory and activating receptors and their functional correlates.

Structural basis of peptide-carbohydrate mimicry in an antibody-combining site.

Transmembrane phosphoprotein Cbp senses cell adhesion signaling mediated by Src family kinase in lipid rafts.

Studies on the structure and dynamics of the human telomeric G quadruplex by single-molecule fluorescence resonance energy transfer.

Cu nanocrystal growth on peptide nanotubes by biomineralization: size control of Cu nanocrystals by tuning peptide conformation.

Interferon-stimulated transcription and innate antiviral immunity require deacetylase activity and histone deacetylase 1.

Distinct hyperpolarizing and relaxant roles for gap junctions and endothelium-derived $H_{2}O_{2}$ in NO-independent relaxations of rabbit arteries

Evaluating plague and smallpox as historical selective pressures for the CCR5-Delta 32 HIV-resistance allele.

Map-based isolation of the leaf rust disease resistance gene Lr10 from the hexaploid wheat (Triticum aestivum L.) genome.

A coarse-grained model for a nanometer-scale molecular pump.

Light- and pH-dependent structural changes in the PsbS subunit of photosystem II.

Measurements of the concentration and composition of nuclei for cirrus formation.

Detection of cancer-specific markers amid massive mass spectral data.

Notch signaling controls multiple steps of pancreatic differentiation.

The atherogenic effect of excess methionine intake.

Rapamycin is active against B-precursor leukemia in vitro and in vivo, an effect that is modulated by IL-7-mediated signaling.

Converting conformational changes to electrostatic energy in molecular motors: The energetics of ATP synthase.

Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor.

Crystal structure of the complete core of archaeal signal recognition particle and implications for interdomain communication.

Myeloperoxidase up-regulates the catalytic activity of inducible nitric oxide synthase by preventing nitric oxide feedback inhibition.

Catalysis and rotation of $F_{1}$ motor: Cleavage of ATP at the catalytic site occurs in 1 ms before 40° substep rotation

Identification of 26RFa, a hypothalamic neuropeptide of the RFamide peptide family with orexigenic activity.

Redox regulation of surface protein thiols: identification of integrin alpha-4 as a molecular target by using redox proteomics.

Mineralized matrix deposition by marrow stromal osteoblasts in 3D perfusion culture increases with increasing fluid shear forces.

The hyperpolarization-activated channel HCN4 is required for the generation of pacemaker action potentials in the embryonic heart

Amino acid substitutions in the thyroglobulin gene are associated with susceptibility to human and murine autoimmune thyroid disease.

Mitotic partitioning and selective reorganization of tissue-specific transcription factors in progeny cells

MED1: a central molecule for maintenance of genome integrity and response to DNA damage.

Biography of Robert A. Lamb.

The molecular basis for the high photosensitivity of rhodopsin.

Use of thiol-disulfide equilibria to measure the energetics of assembly of transmembrane helices in phospholipid bilayers.

CatSper1 required for evoked $Ca^{2+}$ entry and control of flagellar function in sperm

IL-27 regulates IL-12 responsiveness of naive CD4+ T cells through Stat1-dependent and -independent mechanisms.

Expression of conditional fear with and without awareness

Contrasting dynamics in the same plant-herbivore interaction.

A class of sterol 14-demethylase inhibitors as anti-Trypanosoma cruzi agents.

The linear process of somatic evolution.

Determination of the substrate-docking site of protein tyrosine kinase C-terminal Src kinase.

CD24 is a genetic modifier for risk and progression of multiple sclerosis.

Identification and molecular characterization of the G alpha12-Rho guanine nucleotide exchange factor pathway in Caenorhabditis elegans.

Human Mps1 protein kinase is required for centrosome duplication and normal mitotic progression.

Crystal structure of human alpha-tocopherol transfer protein bound to its ligand: implications for ataxia with vitamin E deficiency.

Hyperactivated sperm motility driven by CatSper2 is required for fertilization

Coding potential of laboratory and clinical strains of human cytomegalovirus.

Neural correlates of the emergence of consciousness of thirst.

Rapid $Ca^{2+}-dependent$ decrease of protein ubiquitination at synapses

Labeled cortical mantle distance maps of the cingulate quantify differences between dementia of the Alzheimer type and healthy aging.

Overcoming the hypoxic barrier to radiation therapy with anaerobic bacteria.

Chlorophyll breakdown: pheophorbide a oxygenase is a Rieske-type iron-sulfur protein, encoded by the accelerated cell death 1 gene.

The population structure of Mycobacterium bovis in Great Britain: clonal expansion.

Structures and relative free energies of partially folded states of proteins.

Random Boolean network models and the yeast transcriptional network.

Single-molecule studies of SNARE complex assembly reveal parallel and antiparallel configurations.

A detailed predictive model of the mammalian circadian clock.

Recursions for statistical multiple alignment.

HIV-1-suppressive factors are secreted by CD4+ T cells during primary immune responses.

Control of Bcl-2 expression by reactive oxygen species.

Buoyancy-driven flow in a peat moss layer as a mechanism for solute transport.

Induced-fit recognition of DNA by organometallic complexes with dynamic stereogenic centers.

CD4 T cell memory derived from young naive cells functions well into old age, but memory generated from aged naive cells functions poorly.

NMR-detected hydrogen exchange and molecular dynamics simulations provide structural insight into fibril formation of prion protein fragment 106-126.

Lesion bypass DNA polymerases replicate across non-DNA segments.

Viral protein U counteracts a human host cell restriction that inhibits HIV-1 particle production.

The tandem Src homology 2 domain of the Syk kinase: a molecular device that adapts to interphosphotyrosine distances.

Preferential megalin-mediated transcytosis of low-hormonogenic thyroglobulin: a control mechanism for thyroid hormone release.

A glycopeptide in complex with MHC class I uses the GalNAc residue as an anchor.

Thermodynamic stability of hydrogen clathrates

Analysis of an orf virus chemokine-binding protein: Shifting ligand specificities among a family of poxvirus viroceptors.

A critical role of neural-specific JNK3 for ischemic apoptosis.

A pathway for the metabolism of vitamin D3: unique hydroxylated metabolites formed during catalysis with cytochrome P450scc (CYP11A1).

Thermodynamic treatment of oligonucleotide duplex-simplex equilibria.

A metabolic labeling approach toward proteomic analysis of mucin-type O-linked glycosylation.

Structure and functional significance of mechanically unfolded fibronectin type III1 intermediates.

Intracellular $Ca^{2+}$ and the phospholipid $PIP_{2}$ regulate the taste transduction ion channel TRPM5

Site-specific recombination by the DDE family member mobile element IS30 transposase.

Year: 2003 Volume: 100 Issue: 24

Year: 2003 Volume: 100 Issue: 23

Year: 2003 Volume: 100 Issue: 22

Year: 2003 Volume: 100 Issue: 21

Year: 2003 Volume: 100 Issue: 20

Year: 2003 Volume: 100 Issue: 19

Year: 2003 Volume: 100 Issue: 18

Year: 2003 Volume: 100 Issue: 17

Year: 2003 Volume: 100 Issue: 16

Year: 2003 Volume: 100 Issue: 15

Year: 2003 Volume: 100 Issue: 14

Year: 2003 Volume: 100 Issue: 13

Year: 2003 Volume: 100 Issue: 12

Year: 2003 Volume: 100 Issue: 11

Year: 2003 Volume: 100 Issue: 10

Year: 2003 Volume: 100 Issue: 9

Year: 2003 Volume: 100 Issue: 8

Year: 2003 Volume: 100 Issue: 7

Year: 2003 Volume: 100 Issue: 6

Year: 2003 Volume: 100 Issue: 5

Year: 2003 Volume: 100 Issue: 4

Year: 2003 Volume: 100 Issue: 3

Year: 2003 Volume: 100 Issue: 2

Year: 2003 Volume: 100 Issue: Suppl 2

Year: 2003 Volume: 100 Issue: 1

Year: 2003 Volume: 100 Issue: Suppl 1

Year: 2002 Volume: 99

Year: 2001 Volume: 98

Year: 2000 Volume: 97

Year: 1999 Volume: 96

Year: 1998 Volume: 95

Year: 1997 Volume: 94

Year: 1996 Volume: 93

Year: 1995 Volume: 92

Year: 1994 Volume: 91

Year: 1993 Volume: 90

Year: 1992 Volume: 89

Year: 1991 Volume: 88

Year: 1990 Volume: 87

Year: 1989 Volume: 86

Year: 1988 Volume: 85

Year: 1987 Volume: 84

Year: 1986 Volume: 83

Year: 1985 Volume: 82

Year: 1984 Volume: 81

Year: 1983 Volume: 80

Year: 1982 Volume: 79

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

Regulation of the human GLUT4 gene promoter: interaction between a transcriptional activator and myocyte enhancer factor 2A.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Eyster, Craig A. Griesel, Beth A. Olson, Ann Louise Knight, John B.
Description	Author Affiliation: Knight JB ( Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, P.O. Box 26901, Room 853-BMSB, Oklahoma City, OK 73190, USA.);
Abstract	The GLUT4 gene is subject to complex tissue-specific and metabolic regulation, with a profound impact on insulin-mediated glucose disposal. We have shown, by using transgenic mice, that the human GLUT4 promoter is regulated through the cooperative function of two distinct regulatory elements, domain 1 and the myocyte enhancer factor 2 (MEF2) domain. The MEF2 domain binds transcription factors MEF2A and MEF2D in vivo. Domain I binds a transcription factor, GLUT4 enhancer factor (GEF). In this report, we show a restricted pattern of GEF expression in human tissues, which overlaps with MEF2A only in tissues expressing high levels of GLUT4, suggesting the hypothesis that GEF and MEF2A function together to activate GLUT4 transcription. Data obtained from transiently transfected cells support this hypothesis. Neither GEF nor MEF2A alone significantly activated GLUT4 promoter activity, but increased promoter activity 4- to 5-fold when expressed together. Deletion of the GEF-binding domain (domain I) and the MEF2-binding domain prevented activation, strengthening the conclusion that promoter regulation occurs through these elements. GEF and MEF2A, isolated from nuclei of transfected cells, bound domain I and the MEF2 domain, respectively, which is consistent with activation through these regulatory elements. Finally, GEF and MEF2A coimmunoprecipitated in vivo, strongly supporting a mechanism of GLUT4 transcription activation that depends on this protein-protein interaction.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	25
Volume Number	100
Language	English
Publisher	National Academy of Sciences
Publisher Date	2003-12-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	DNA-Binding Proteins Chemistry Gene Expression Regulation Monosaccharide Transport Proteins Genetics Muscle Proteins Promoter Regions, Genetic Transcription Factors Biosynthesis Transcriptional Activation Animals Blotting, Northern Blotting, Western COS Cells Cell Nucleus Metabolism Genes, Reporter Glucose Glucose Transporter Type 4 Glutathione Transferase Green Fluorescent Proteins Luminescent Proteins MADS Domain Proteins MEF2 Transcription Factors Mice Mice, Transgenic Microscopy, Confocal Myogenic Regulatory Factors Precipitin Tests Protein Binding Protein Structure, Tertiary Recombinant Fusion Proteins Tissue Distribution Transcription, Genetic Transfection Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in