NDLI: Leukocyte-inspired biodegradable particles that selectively and avidly adhere to inflamed endothelium in vitro and in vivo.

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Leukocyte-inspired biodegradable particles that selectively and avidly adhere to inflamed endothelium in vitro and in vivo.

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Leukocyte-inspired biodegradable particles that selectively and avidly adhere to inflamed endothelium in vitro and in vivo.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Ansari, Ramin Sakhalkar, Harshad S. Dalal, Milind K. Kurjiaka, David T. Salem, Aliasger K. Fu, Jie Hanes, Justin Goetz, Douglas J. Shakesheff, Kevin M. Kiani, Mohammad F.
Description	Author Affiliation: Sakhalkar HS ( Departments of Chemical Engineering and Biological Sciences, Ohio University, Athens, OH 45701, USA.);
Abstract	We exploited leukocyte-endothelial cell adhesion chemistry to generate biodegradable particles that exhibit highly selective accumulation on inflamed endothelium in vitro and in vivo. Leukocyte-endothelial cell adhesive particles exhibit up to 15-fold higher adhesion to inflamed endothelium, relative to noninflamed endothelium, under in vitro flow conditions similar to that present in blood vessels, a 6-fold higher adhesion to cytokine inflamed endothelium relative to non-cytokine-treated endothelium in vivo, and a 10-fold enhancement in adhesion to trauma-induced inflamed endothelium in vivo due to the addition of a targeting ligand. The leukocyte-inspired particles have adhesion efficiencies similar to that of leukocytes and were shown to target each of the major inducible endothelial cell adhesion molecules (E-selectin, P-selectin, vascular cell adhesion molecule 1, and intercellular adhesion molecule 1) that are up-regulated at sites of pathological inflammation. The potential for targeted drug delivery to inflamed endothelium has significant implications for the improved treatment of an array of pathologies, including cardiovascular disease, arthritis, inflammatory bowel disease, and cancer.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	26
Volume Number	100
Language	English
Publisher	National Academy of Sciences
Publisher Date	2003-12-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Cell Adhesion Physiology Endothelium, Vascular Physiopathology Inflammation Leukocytes Antibodies, Monoclonal Cells, Cultured E-Selectin Immunology Blood Intercellular Adhesion Molecule-1 Cytology Microscopy Umbilical Veins Vascular Cell Adhesion Molecule-1 Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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