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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Takaiwa, Fumio Takagi, Hidenori Hiroi, Takachika Yang, Lijun Kawauchi, Hideyuki Tada, Yoshifumi Ishimitsu, Ryotaro Yuki, Yoshikazu Takamura, Kaoru Kiyono, Hiroshi |
| Description | Author Affiliation: Takagi H ( Plant Biotechnology Department, National Institute of Agrobiological Sciences, Tsukuba, Ibaraki 305-8602, Japan.); |
| Abstract | Peptide immunotherapy using multiple predominant allergen-specific T cell epitopes is a safe and promising strategy for the control of type I allergy. In this study, we developed transgenic rice plants expressing mouse dominant T cell epitope peptides of Cry j I and Cry j II allergens of Japanese cedar pollen as a fusion protein with the soybean seed storage protein glycinin. Under the control of the rice seed storage protein glutelin GluB-1 promoter, the fusion protein was specifically expressed and accumulated in seeds at a level of 0.5% of the total seed protein. Oral feeding to mice of transgenic rice seeds expressing the T cell epitope peptides of Cry j I and Cry j II before systemic challenge with total protein of cedar pollen inhibited the development of allergen-specific serum IgE and IgG antibody and CD4(+) T cell proliferative responses. The levels of allergen-specific CD4(+) T cell-derived allergy-associated T helper 2 cytokine production of IL-4, IL-5, and IL-13 and histamine release in serum were significantly decreased. Moreover, the development of pollen-induced clinical symptoms was inhibited in our experimental sneezing mouse model. These results indicate the potential of transgenic rice seeds in production and mucosal delivery of allergen-specific T cell epitope peptides for the induction of oral tolerance to pollen allergens. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 48 |
| Volume Number | 102 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2005-11-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | CD4-Positive T-Lymphocytes Immunology Epitopes, T-Lymphocyte Metabolism Hypersensitivity Prevention & Control Immunoglobulin E Immunotherapy Oryza Sativa Vaccines Allergens Animals Antigens, Plant Cryptomeria Globulins Glutens Genetics Mice Mice, Inbred BALB C Plant Proteins Plants, Genetically Modified Pollen Promoter Regions, Genetic Soybean Proteins Comparative Study Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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