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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Matsumoto, Shingo Yamada, Ken-ichi Nagai, Mika Utsumi, Hideo Ichikawa, Kazuhiro Sakai, Kiyoshi Kinoshita, Yuichi |
| Description | Author Affiliation: Utsumi H ( Department of Bio-Functional Science, Graduate School of Pharmaceutical Sciences, Kyushu University, Higashi-ku, Fukuoka 812-8582, Japan. utsumi@pch.phar.kyushu-u.ac.jp); |
| Abstract | MRI has provided significant clinical utility in the diagnosis of diseases and will become a powerful tool to assess phenotypic changes in genetically engineered animals. Overhauser enhanced MRI (OMRI), which is a double resonance technique, creates images of free radical distributions in small animals by enhancing the water proton signal intensity by means of the Overhauser effect. Several studies have demonstrated noninvasive assessment of reactive oxygen species generation in small animals by using low frequency electron spin resonance (ESR) spectroscopy/imaging and nitroxyl radicals. In vivo ESR signal intensities of nitroxyl radicals decrease with time after injection; and the decreases are enhanced by reactive oxygen species, generated in oxidative disease models in a site-specific manner. In this study, we show images of nitroxyl radicals with different isotopes by changing the external magnetic field for ESR irradiation between (14)N and (15)N nuclei in field-cycled OMRI. OMRI simultaneously obtained dual images of two individual chemical processes. Oxidation and reduction were monitored in a rate-dependent manner at nanometer scale by labeling membrane-permeable and -impermeable nitroxyl radicals with (14)N and (15)N nuclei. Phantom objects containing ascorbic acid-encapsulated liposomes with membrane-permeable radicals but not membrane-impermeable ones show a time-dependent decrease of the OMRI image intensity. The pharmacokinetics in mice was assessed with OMRI after radical administration. This OMRI technique with dual probes should offer significant applicability to nanometer scale molecular imaging and simultaneous assessment of independent processes in gene-modified animals. Thus, it may become a powerful tool to clarify mechanisms of disease and to monitor pharmaceutical therapy. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 5 |
| Volume Number | 103 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2006-02-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Magnetic Resonance Imaging Nitrogen Oxides Oxidation-Reduction Animals Cell Membrane Metabolism Electron Spin Resonance Spectroscopy Free Radicals Image Processing, Computer-Assisted Liposomes Chemistry Mice Models, Genetic Nanotechnology Oxygen Phantoms, Imaging Spin Labels Time Factors Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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