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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Park, Young-jun Luger, Karolin |
| Description | Author Affiliation: Park YJ ( Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO 80523-1870, USA.); |
| Abstract | Nucleosome assembly protein 1 (NAP-1) is an integral component in the establishment, maintenance, and dynamics of eukaryotic chromatin. It shuttles histones into the nucleus, assembles nucleosomes, and promotes chromatin fluidity, thereby affecting the transcription of many genes. The 3.0 A crystal structure of yeast NAP-1 reveals a previously uncharacterized fold with implications for histone binding and shuttling. A long alpha-helix is responsible for homodimerization via a previously uncharacterized antiparallel non-coiled-coil, and an alpha/beta domain is implicated in protein-protein interaction. A nuclear export sequence that is embedded in the dimerization helix is almost completely masked by an accessory domain that contains several target sites for casein kinase II. The four-stranded antiparallel beta-sheet that characterizes the alpha/beta domain is found in all histone chaperones, despite the absence of homology in sequence, structural context, or quaternary structure. To our knowledge, this is the first structure of a member of the large NAP family of proteins and suggests a mechanism by which the shuttling of histones to and from the nucleus is regulated. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 5 |
| Volume Number | 103 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2006-02-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Cell Cycle Proteins Chemistry Nuclear Proteins Saccharomyces Cerevisiae Metabolism Amino Acid Motifs Amino Acid Sequence Animals Cell Nucleus Crystallography, X-Ray Cytoplasm Dimerization Fungal Proteins Histones Models, Molecular Molecular Chaperones Molecular Sequence Data Mutation Nucleosome Assembly Protein 1 Protein Binding Protein Conformation Protein Folding Protein Structure, Secondary Protein Structure, Tertiary Recombinant Proteins Saccharomyces Cerevisiae Proteins Sequence Homology, Amino Acid Spectrometry, Fluorescence Static Electricity Research Support, N.I.H., Extramural Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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