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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Titta, Francesca Comanducci, Maurizio Aricò, Beatrice Capecchi, Barbara Cinotti, Vanda Ferlicca, Francesca Mannucci, Donatella Savino, Silvana Adu-bobie, Jeannette Brunelli, Brunella Masignani, Vega Contorni, Mario Bartalesi, Alessandro Veggi, Daniele Cartocci, Elena Bambini, Stefania Luzzi, Enrico Granoff, Dan Serruto, Davide Morandi, Maurizio Biolchi, Alessia Ovidi, Elisa Galli, Barbara Rappuoli, Rino Giuliani, Marzia M. Ciucchi, Laura Di Marcello, Federica Pizza, Mariagrazia Santini, Laura Welsch, Jo Anne |
| Description | Author Affiliation: Giuliani MM ( Novartis Vaccines, Via Fiorentina 1, 53100 Siena, Italy.); |
| Abstract | Meningitis and sepsis caused by serogroup B meningococcus are two severe diseases that still cause significant mortality. To date there is no universal vaccine that prevents these diseases. In this work, five antigens discovered by reverse vaccinology were expressed in a form suitable for large-scale manufacturing and formulated with adjuvants suitable for human use. The vaccine adjuvanted by aluminum hydroxide induced bactericidal antibodies in mice against 78% of a panel of 85 meningococcal strains representative of the global population diversity. The strain coverage could be increased to 90% and above by the addition of CpG oligonucleotides or by using MF59 as adjuvant. The vaccine has the potential to conquer one of the most devastating diseases of childhood. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 29 |
| Volume Number | 103 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2006-07-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Meningococcal Vaccines Immunology Neisseria Meningitidis, Serogroup B Animals Antibodies Antigens, Bacterial Disease Models, Animal Meningitis, Meningococcal Microbiology Prevention & Control Mice Microscopy, Electron, Transmission Classification Ultrastructure Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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