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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Yuan, Xu Zhang, Kang Ding, Sheng Efe, Jem A. Talantova, Maria Kim, Janghwan Wang, Shufen Zhu, Saiyong Lipton, Stuart A. |
| Description | Author Affiliation: Kim J ( Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA.); |
| Abstract | The simple yet powerful technique of induced pluripotency may eventually supply a wide range of differentiated cells for cell therapy and drug development. However, making the appropriate cells via induced pluripotent stem cells (iPSCs) requires reprogramming of somatic cells and subsequent redifferentiation. Given how arduous and lengthy this process can be, we sought to determine whether it might be possible to convert somatic cells into lineage-specific stem/progenitor cells of another germ layer in one step, bypassing the intermediate pluripotent stage. Here we show that transient induction of the four reprogramming factors (Oct4, Sox2, Klf4, and c-Myc) can efficiently transdifferentiate fibroblasts into functional neural stem/progenitor cells (NPCs) with appropriate signaling inputs. Compared with induced neurons (or iN cells, which are directly converted from fibroblasts), transdifferentiated NPCs have the distinct advantage of being expandable in vitro and retaining the ability to give rise to multiple neuronal subtypes and glial cells. Our results provide a unique paradigm for iPSC-factor-based reprogramming by demonstrating that it can be readily modified to serve as a general platform for transdifferentiation. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 19 |
| Volume Number | 108 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2011-05-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Cell Transdifferentiation Fibroblasts Cytology Metabolism Neural Stem Cells Animals Cell Lineage Cell Proliferation Culture Media Cytological Techniques Gene Expression Induced Pluripotent Stem Cells Kruppel-Like Transcription Factors Biosynthesis Mice Models, Biological Octamer Transcription Factor-3 Genetics Promoter Regions, Genetic Proto-Oncogene Proteins C-myc SOXB1 Transcription Factors Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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