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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Vergara-irigaray, Marta Villanueva, Maite De Los Mozos, Igor Ruiz Valle, Jaione Toledo-arana, Alejandro Penadés, José R. Solano, Cristina Lasa, Iñigo Dobin, Alexander Segura, Víctor Gingeras, Thomas R. Fagegaltier, Delphine |
| Description | Author Affiliation: Lasa I ( Laboratory of Microbial Biofilms, Instituto de Agrobiotecnología, Consejo Superior de Investigaciones Científicas-Universidad Pública de Navarra-Gobierno de Navarra, 31006 Pamplona, Spain. ilasa@unavarra.es); |
| Abstract | RNA deep sequencing technologies are revealing unexpected levels of complexity in bacterial transcriptomes with the discovery of abundant noncoding RNAs, antisense RNAs, long 5' and 3' untranslated regions, and alternative operon structures. Here, by applying deep RNA sequencing to both the long and short RNA fractions (<50 nucleotides) obtained from the major human pathogen Staphylococcus aureus, we have detected a collection of short RNAs that is generated genome-wide through the digestion of overlapping sense/antisense transcripts by RNase III endoribonuclease. At least 75% of sense RNAs from annotated genes are subject to this mechanism of antisense processing. Removal of RNase III activity reduces the amount of short RNAs and is accompanied by the accumulation of discrete antisense transcripts. These results suggest the production of pervasive but hidden antisense transcription used to process sense transcripts by means of creating double-stranded substrates. This process of RNase III-mediated digestion of overlapping transcripts can be observed in several evolutionarily diverse Gram-positive bacteria and is capable of providing a unique genome-wide posttranscriptional mechanism to adjust mRNA levels. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 50 |
| Volume Number | 108 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2011-12-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Genome, Bacterial Genetics RNA Processing, Post-Transcriptional RNA, Antisense RNA, Messenger Staphylococcus Aureus Transcription, Genetic Gene Expression Regulation, Bacterial Open Reading Frames Metabolism RNA, Bacterial RNA, Double-Stranded Ribonuclease III Sequence Analysis, RNA Species Specificity Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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