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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Ridder, Dirk A. Penuela, Silvia Herb, Anne Hormuzdi, Sheriar G. Monyer, Hannah Bargiotas, Panagiotis Von Engelhardt, Jakob Krenz, Antje Barakat, Waleed Schwaninger, Markus |
| Description | Author Affiliation: Bargiotas P ( Institute of Experimental and Clinical Pharmacology and Toxicology, University of Lübeck, 23538 Lubeck, Germany.); |
| Abstract | Pannexin 1 (Px1, Panx1) and pannexin 2 (Px2, Panx2) form large-pore nonselective channels in the plasma membrane of cells and were suggested to play a role in the pathophysiology of cerebral ischemia. To directly test a potential contribution of pannexins in ischemia-related mechanisms, we performed experiments in Px1(-/-), Px2(-/-), and Px1(-/-)Px2(-/-) knockout mice. IL-1ß release, channel function in astrocytes, and cortical spreading depolarization were not altered in Px1(-/-)Px2(-/-) mice, indicating that, in contrast to previous concepts, these processes occur normally in the absence of pannexin channels. However, ischemia-induced dye release from cortical neurons was lower, indicating that channel function in Px1(-/-)Px2(-/-) neurons was impaired. Furthermore, Px1(-/-)Px2(-/-) mice had a better functional outcome and smaller infarcts than wild-type mice when subjected to ischemic stroke. In conclusion, our data demonstrate that Px1 and Px2 underlie channel function in neurons and contribute to ischemic brain damage. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 51 |
| Volume Number | 108 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2011-12-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Connexins Metabolism Gene Expression Regulation Ischemia Pathology Nerve Tissue Proteins Neurodegenerative Diseases Adenosine Triphosphate Chemistry Animals Brain Ischemia Genetics Gap Junctions Infarction, Middle Cerebral Artery Interleukin-1beta Macrophages Mice Mice, Knockout Mice, Transgenic Neurons Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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