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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Bräutigam, Lars Schütte, Lena Dorothee Berndt, Carsten Prozorovski, Timour Gellert, Manuela Godoy, José Rodrigo Holmgren, Arne Hauptmann, Giselbert Lillig, Christopher Horst |
| Description | Author Affiliation: Bräutigam L ( Division of Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Scheeles Väg 2, 17177 Stockholm, Sweden.); |
| Abstract | Cellular functions and survival are dependent on a tightly controlled redox potential. Currently, an increasing amount of data supports the concept of local changes in the redox environment and specific redox signaling events controlling cell function. Specific protein thiol groups are the major targets of redox signaling and regulation. Thioredoxins and glutaredoxins catalyze reversible thiol-disulfide exchange reactions and are primary regulators of the protein thiol redox state. Here, we demonstrate that embryonic brain development depends on the enzymatic activity of glutaredoxin 2. Zebrafish with silenced expression of glutaredoxin 2 lost virtually all types of neurons by apoptotic cell death and the ability to develop an axonal scaffold. As demonstrated in zebrafish and in a human cellular model for neuronal differentiation, glutaredoxin 2 controls axonal outgrowth via thiol redox regulation of collapsin response mediator protein 2, a central component of the semaphorin pathway. This study provides an example of a specific thiol redox regulation essential for vertebrate embryonic development. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 51 |
| Volume Number | 108 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2011-12-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Brain Embryology Gene Expression Regulation, Developmental Glutaredoxins Chemistry Zebrafish Animals Apoptosis Axons Physiology Cell Line, Tumor Developmental Biology Genetics Neurites Metabolism Oxidation-Reduction Recombinant Proteins Signal Transduction Vertebrates Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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