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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Tommassen-van Boxtel, Ria Baldus, Marc Bos, Martine P. Post, Jan Andries Tommassen, Jan Renault, Marie |
| Description | Author Affiliation: Renault M ( Bijvoet Center for Biomolecular Research, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands.); |
| Abstract | Decrypting the structure, function, and molecular interactions of complex molecular machines in their cellular context and at atomic resolution is of prime importance for understanding fundamental physiological processes. Nuclear magnetic resonance is a well-established imaging method that can visualize cellular entities at the micrometer scale and can be used to obtain 3D atomic structures under in vitro conditions. Here, we introduce a solid-state NMR approach that provides atomic level insights into cell-associated molecular components. By combining dedicated protein production and labeling schemes with tailored solid-state NMR pulse methods, we obtained structural information of a recombinant integral membrane protein and the major endogenous molecular components in a bacterial environment. Our approach permits studying entire cellular compartments as well as cell-associated proteins at the same time and at atomic resolution. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 13 |
| Volume Number | 109 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2012-03-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Escherichia Coli Cytology Metabolism Magnetic Resonance Spectroscopy Amino Acid Sequence Bacterial Outer Membrane Proteins Chemistry Cell Membrane Escherichia Coli Proteins Lipopolysaccharides Lipoproteins Molecular Sequence Data Peptidoglycan Protein Conformation Proteolipids Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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