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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Heath, Jennifer N. Mcsorley, Stephen J. Msefula, Chisomo L. Felgner, Philip L. Lee, Seung-joo Kayala, Matthew A. Juarez, Silvia Nanton, Minelva R. Hart, Peter Liang, Li Davies, D. Huw Tsolis, Renée M. Maclennan, Calman A. Necchi, Francesca Gondwe, Esther N. Heyderman, Robert S. |
| Spatial Coverage | Malawi |
| Description | Author Affiliation: Lee SJ ( Center for Comparative Medicine, Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA.); |
| Abstract | Despite the importance of Salmonella infections in human and animal health, the target antigens of Salmonella-specific immunity remain poorly defined. We have previously shown evidence for antibody-mediating protection against invasive Salmonellosis in mice and African children. To generate an overview of antibody targeting in systemic Salmonellosis, a Salmonella proteomic array containing over 2,700 proteins was constructed and probed with immune sera from Salmonella-infected mice and humans. Analysis of multiple inbred mouse strains identified 117 antigens recognized by systemic antibody responses in murine Salmonellosis. Importantly, many of these antigens were independently identified as target antigens using sera from Malawian children with Salmonella bacteremia, validating the study of the murine model. Furthermore, vaccination with SseB, the most prominent antigenic target in Malawian children, provided mice with significant protection against Salmonella infection. Together, these data uncover an overlapping immune signature of disseminated Salmonellosis in mice and humans and provide a foundation for the generation of a protective subunit vaccine. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 13 |
| Volume Number | 109 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2012-03-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Salmonella Infections, Animal Immunology Salmonella Infections Animals Antibody Formation Antigens, Bacterial Bacterial Proteins Blood Bactericidal Activity Child, Preschool Convalescence Infant Infant, Newborn Malawi Mice Mice, Inbred Strains Protein Array Analysis Reproducibility Of Results Blood Vaccination Vaccines, Attenuated Vaccines, Subunit Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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