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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Hibbett, David S. Coutinho, Pedro M. Fernandez-fueyo, Elena Lapidus, Alla Syed, Khajamohiddin St John, Franz J. Vanden Wymelenberg, Amber Yadav, Jagjit S. Floudas, Dimitrios Hammel, Kenneth E. Henrissat, Bernard Doddapaneni, Harshavardhan Sabat, Grzegorz Seelenfreund, Daniela Splinter Bondurant, Sandra Barry, Kerrie W. Lindquist, Erika A. Lucas, Susan M. James, Tim Y. Santoyo, Francisco Oguiza, José A. Hori, Chiaki Lobos, Sergio Labutti, Kurt M. Lombard, Vincent Magnuson, Jon Karl Master, Emma Honda, Yoichi Ryu, Jae San Polanco, Rubén Samejima, Masahiro Pisabarro, Antonio G. Ruiz-dueñas, Francisco J. Ramirez, Lucia Gaskell, Jill Lavín, José L. Subramanian, Venkataramanan Schmoll, Monika Kües, Ursula Ferreira, Patricia Watanabe, Takahito Larrondo, Luis F. Perez, Gumer Igarashi, Kiyohiko Tello, Mario Watanabe, Takashi Kubicek, Christian P. Held, Benjamin W. Canessa, Paulo San, Ryu Jae |
| Description | Author Affiliation: Fernandez-Fueyo E ( Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Cientificas, E-28040 Madrid, Spain.); |
| Abstract | Efficient lignin depolymerization is unique to the wood decay basidiomycetes, collectively referred to as white rot fungi. Phanerochaete chrysosporium simultaneously degrades lignin and cellulose, whereas the closely related species, Ceriporiopsis subvermispora, also depolymerizes lignin but may do so with relatively little cellulose degradation. To investigate the basis for selective ligninolysis, we conducted comparative genome analysis of C. subvermispora and P. chrysosporium. Genes encoding manganese peroxidase numbered 13 and five in C. subvermispora and P. chrysosporium, respectively. In addition, the C. subvermispora genome contains at least seven genes predicted to encode laccases, whereas the P. chrysosporium genome contains none. We also observed expansion of the number of C. subvermispora desaturase-encoding genes putatively involved in lipid metabolism. Microarray-based transcriptome analysis showed substantial up-regulation of several desaturase and MnP genes in wood-containing medium. MS identified MnP proteins in C. subvermispora culture filtrates, but none in P. chrysosporium cultures. These results support the importance of MnP and a lignin degradation mechanism whereby cleavage of the dominant nonphenolic structures is mediated by lipid peroxidation products. Two C. subvermispora genes were predicted to encode peroxidases structurally similar to P. chrysosporium lignin peroxidase and, following heterologous expression in Escherichia coli, the enzymes were shown to oxidize high redox potential substrates, but not Mn(2+). Apart from oxidative lignin degradation, we also examined cellulolytic and hemicellulolytic systems in both fungi. In summary, the C. subvermispora genetic inventory and expression patterns exhibit increased oxidoreductase potential and diminished cellulolytic capability relative to P. chrysosporium. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 14 |
| Volume Number | 109 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2012-04-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Basidiomycota Genetics Genomics Lignin Metabolism Classification Hydrolysis Molecular Sequence Data Oxidation-Reduction Phylogeny Species Specificity Comparative Study Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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