NDLI: Lantibiotics from Geobacillus thermodenitrificans.

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Lantibiotics from Geobacillus thermodenitrificans.

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Lantibiotics from Geobacillus thermodenitrificans.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Goto, Yuki Garg, Neha Nair, Satish K. Tang, Weixin Van Der Donk, Wilfred A.
Description	Author Affiliation: Garg N ( Department of Biochemistry, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana, IL 61801, USA.);
Abstract	The lantibiotic nisin has been used as an effective food preservative to combat food-borne pathogens for over 40 y. Despite this successful use, nisin's stability at pH 7 is limited. Herein, we describe a nisin analog encoded on the genome of the thermophilic bacterium Geobacillus thermodenitrificans NG80-2. This analog termed geobacillin I was obtained by heterologous expression in Escherichia coli and subsequent purification. Extensive NMR characterization demonstrated that geobacillin I contains seven thioether cross-links, two more than the five cross-links found in nisin and the most cross-links found in any lantibiotic to date. The antimicrobial spectrum of geobacillin I was generally similar to that of nisin A, with increased activity against Streptococcus dysgalactiae, one of the causative agents of bovine mastitis. Geobacillin I demonstrated increased stability compared to nisin A. In addition to geobacillin I, the genome of G. thermodenitrificans NG80-2 also contains a class II lantibiotic biosynthetic gene cluster. The corresponding compound was produced in E. coli, and has a ring topology different than that of any known lantibiotic as determined by tandem mass spectrometry. Interestingly, geobacillin II only demonstrated antimicrobial activity against Bacillus strains. Seven Geobacillus strains were screened for production of the geobacillins using whole-cell MALDI-MS and five were shown to produce geobacillin I, but none produced geobacillin II.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	14
Volume Number	109
Language	English
Publisher	National Academy of Sciences
Publisher Date	2012-04-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Bacteriocins Isolation & Purification Geobacillus Metabolism Amino Acid Sequence Chemistry Pharmacology Magnetic Resonance Spectroscopy Molecular Sequence Data Molecular Structure Sequence Homology, Amino Acid Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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