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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Narum, David L. Leto, Thomas L. Yager, Stephanie B. Miller, Louis H. Francischetti, Ivo M. B. Lukszo, Jan Pierce, Susan K. Cerqueira, Gustavo C. Lu, Jinghua Miura, Kazutoyo Porcella, Stephen F. Gera, Nidhi Barbian, Kent D. Srinivasan, Prakash El-sayed, Najib Waisberg, Michael Rada, Balazs |
| Description | Author Affiliation: Waisberg M ( Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA. waisbergm@niaid.nih.gov); |
| Abstract | The malaria parasite, Plasmodium falciparum, and the human immune system have coevolved to ensure that the parasite is not eliminated and reinfection is not resisted. This relationship is likely mediated through a myriad of host–parasite interactions, although surprisingly few such interactions have been identified. Here we show that the 33-kDa fragment of P. falciparum merozoite surface protein 1 $(MSP1_{33}),$ an abundant protein that is shed during red blood cell invasion, binds to the proinflammatory protein, S100P. $MSP1_{33}$ blocks S100P-induced NFκB activation in monocytes and chemotaxis in neutrophils. Remarkably, S100P binds to both dimorphic alleles of MSP1, estimated to have diverged >27 Mya, suggesting an ancient, conserved relationship between these parasite and host proteins that may serve to attenuate potentially damaging inflammatory responses. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 14 |
| Volume Number | 109 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2012-04-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Calcium-Binding Proteins Antagonists & Inhibitors Merozoite Surface Protein 1 Physiology Neoplasm Proteins Plasmodium Falciparum Metabolism Amino Acid Sequence Animals Chemistry Chromatography, Gel Electrophoresis, Polyacrylamide Gel Enzyme-Linked Immunosorbent Assay Microscopy, Confocal Molecular Sequence Data Sequence Homology, Amino Acid Surface Plasmon Resonance Research Support, N.I.H., Intramural Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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