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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Eloy, Nubia B. Van Leene, Jelle Witters, Erwin Vanhaeren, Hannes Ferreira, Paulo C. G. De Milde, Liesbeth Maleux, Katrien Vercruysse, Leen Inzé, Dirk Gonzalez, Nathalie Dhondt, Stijn Remaut, Han Mercier, Raphaël Cromer, Laurence Beemster, Gerrit T. S. Van Montagu, Marc C. E. De Jaeger, Geert |
| Description | Author Affiliation: Eloy NB ( Department of Plant Systems Biology, VIB, Ghent University, 9052 Ghent, Belgium.); |
| Abstract | The anaphase-promoting complex/cyclosome (APC/C) is a large multiprotein E3 ubiquitin ligase involved in ubiquitin-dependent proteolysis of key cell cycle regulatory proteins, including the destruction of mitotic cyclins at the metaphase-to-anaphase transition. Despite its importance, the role of the APC/C in plant cells and the regulation of its activity during cell division remain poorly understood. Here, we describe the identification of a plant-specific negative regulator of the APC/C complex, designated SAMBA. In Arabidopsis thaliana, SAMBA is expressed during embryogenesis and early plant development and plays a key role in organ size control. Samba mutants produced larger seeds, leaves, and roots, which resulted from enlarged root and shoot apical meristems, and, additionally, they had a reduced fertility attributable to a hampered male gametogenesis. Inactivation of SAMBA stabilized A2-type cyclins during early development. Our data suggest that SAMBA regulates cell proliferation during early development by targeting CYCLIN A2 for APC/C-mediated proteolysis. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 34 |
| Volume Number | 109 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2012-08-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Arabidopsis Genetics Metabolism Cyclin A Chemistry Mutation Ubiquitin-Protein Ligase Complexes Physiology Amino Acid Sequence Anaphase-Promoting Complex-Cyclosome Cell Cycle Gene Expression Regulation, Plant Models, Biological Models, Genetic Molecular Sequence Data Phenotype Plant Proteins Pollen Sequence Homology, Amino Acid Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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