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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Grotenbreg, Gijsbert M. Guillen, Eduardo Hu, Chih-chi Andrew Jaenisch, Rudolf Ogata, Souichi Ploegh, Hidde L. Dougan, Stephanie K. |
| Description | Author Affiliation: Dougan SK ( Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.); |
| Abstract | We used somatic cell nuclear transfer (SCNT) to generate a mouse from the nucleus of an IgG1(+) ovalbumin-specific B cell. The resulting OBI mice show generally normal B-cell development, with elevated percentages of marginal zone B cells and a reduction in B-1 B cells. Whereas OBI RAG1(-/-) mice have exclusively IgG1 anti-ovalbumin in their serum, OBI mice show elevated levels of anti-ovalbumin of nearly all isotypes 3' of the γ1 constant region in the IgH locus, indicating that class switch recombination (CSR) occurs in the absence of immunization with ovalbumin. This CSR is associated with the presence of IgM(+)IgG1(+) double producer B cells that represent <1% of total B cells, accumulate in the peritoneal cavity, and account for near-normal levels of serum IgM and IgG3. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 34 |
| Volume Number | 109 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2012-08-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | B-Lymphocytes Immunology Metabolism Cell Nucleus Immunoglobulin G Biosynthesis Alleles Animals Cell Separation Crosses, Genetic Immunoglobulin Class Switching Genetics Immunoglobulin M Mice Mice, Inbred BALB C Nuclear Transfer Techniques Recombination, Genetic Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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