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| Content Provider | PubMed Central |
|---|---|
| Author | Eloy, Nubia B. Gonzalez, Nathalie Leene, Jelle Van Maleux, Katrien Hannes, Vanhaeren Milde, Liesbeth De Dhondt, Stijn Vercruysse, Leen Witters, Erwin Mercier, Raphaël Cromer, Laurence Beemster, Gerrit T. S. Han, Remaut Montagu, Marc C. E. Van Jaeger, Geert De Ferreira, Paulo C. G. Inzé, Dirk |
| Abstract | The anaphase-promoting complex/cyclosome (APC/C) is a large multiprotein E3 ubiquitin ligase involved in ubiquitin-dependent proteolysis of key cell cycle regulatory proteins, including the destruction of mitotic cyclins at the metaphase-to-anaphase transition. Despite its importance, the role of the APC/C in plant cells and the regulation of its activity during cell division remain poorly understood. Here, we describe the identification of a plant-specific negative regulator of the APC/C complex, designated SAMBA. In Arabidopsis thaliana, SAMBA is expressed during embryogenesis and early plant development and plays a key role in organ size control. Samba mutants produced larger seeds, leaves, and roots, which resulted from enlarged root and shoot apical meristems, and, additionally, they had a reduced fertility attributable to a hampered male gametogenesis. Inactivation of SAMBA stabilized A2-type cyclins during early development. Our data suggest that SAMBA regulates cell proliferation during early development by targeting CYCLIN A2 for APC/C-mediated proteolysis. |
| Related Links | http://dx.doi.org/10.1073/pnas.1211418109 |
| Ending Page | 13858 |
| Page Count | 6 |
| Starting Page | 13853 |
| File Format | |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 34 |
| Volume Number | 109 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2012-08-21 |
| Access Restriction | Open |
| Rights Holder | National Academy of Sciences |
| Subject Keyword | General Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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