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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Rajendran, Lawrence Zurbriggen, Sebastian Bali, Jitin Gheinani, Ali Hashemi |
| Description | Author Affiliation: Bali J ( Systems and Cell Biology of Neurodegeneration, Division of Psychiatry Research, University of Zurich, 8008 Zurich, Switzerland.); |
| Abstract | Alzheimer's disease (AD) is characterized by the presence of toxic protein aggregates or plaques composed of the amyloid ß (Aß) peptide. Various lengths of Aß peptide are generated by proteolytic cleavages of the amyloid precursor protein (APP). Mutations in many familial AD-associated genes affect the production of the longer Aß42 variant that preferentially accumulates in plaques. In the case of sporadic or late-onset AD, which accounts for greater than 95% of cases, several genes are implicated in increasing the risk, but whether they also cause the disease by altering amyloid levels is currently unknown. Through loss of function studies in a model cell line, here RNAi-mediated silencing of several late onset AD genes affected Aß levels is shown. However, unlike the genes underlying familial AD, late onset AD-susceptibility genes do not specifically alter the Aß42/40 ratios and suggest that these genes probably contribute to AD through distinct mechanisms. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 38 |
| Volume Number | 109 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2012-09-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Alzheimer Disease Genetics Amyloid Beta-Peptides Chemistry Peptide Fragments Age Of Onset Cell Proliferation Cystatins Epistasis, Genetic Gene Silencing Genetic Predisposition To Disease Genetic Variation Genome-Wide Association Study HeLa Cells Models, Genetic Mutation Plaque, Amyloid Metabolism RNA Interference Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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