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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Citovsky, Vitaly Zaltsman, Adi Gafni, Yedidya Lacroix, Benoît |
| Description | Author Affiliation: Zaltsman A ( Department of Biochemistry and Cell Biology, State University of New York, Stony Brook, NY 11794, USA.); |
| Abstract | One the most intriguing, yet least studied, aspects of the bacterium-host plant interaction is the role of the host ubiquitin/proteasome system (UPS) in the infection process. Increasing evidence indicates that pathogenic bacteria subvert the host UPS to facilitate infection. Although both mammalian and plant bacterial pathogens are known to use the host UPS, the first prokaryotic F-box protein, an essential component of UPS, was identified in Agrobacterium. During its infection, which culminates in genetic modification of the host cell, Agrobacterium transfers its T-DNA--as a complex (T-complex) with the bacterial VirE2 and host VIP1 proteins--into the host cell nucleus. There the T-DNA is uncoated from its protein components before undergoing integration into the host genome. It has been suggested that the host UPS mediates this uncoating process, but there is no evidence indicating that this activity can unmask the T-DNA molecule. Here we provide support for the idea that the plant UPS uncoats synthetic T-complexes via the Skp1/Cullin/F-box protein VBF pathway and exposes the T-DNA molecule to external enzymatic activity. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 1 |
| Volume Number | 110 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2013-01-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Agrobacterium Genetics Bacterial Proteins Metabolism DNA, Bacterial Macromolecular Substances Proteasome Endopeptidase Complex Transformation, Genetic Physiology Active Transport, Cell Nucleus Arabidopsis Proteins Blotting, Western DNA Primers DNA-Binding Proteins Host-Pathogen Interactions Ion Channels Reverse Transcriptase Polymerase Chain Reaction Tobacco Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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