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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Colmont, Chantal S. Telford, William G. Reed, Simon H. Patel, Girish K. Hawk, Nga V. Yee, Carole L. Ohyama, Manabu Udey, Mark C. Benketah, Antisar Vogel, Jonathan C. |
| Description | Author Affiliation: Colmont CS ( Department of Dermatology and Wound Healing, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom.); |
| Abstract | Smoothened antagonists directly target the genetic basis of human basal cell carcinoma (BCC), the most common of all cancers. These drugs inhibit BCC growth, but they are not curative. Although BCC cells are monomorphic, immunofluorescence microscopy reveals a complex hierarchical pattern of growth with inward differentiation along hair follicle lineages. Most BCC cells express the transcription factor KLF4 and are committed to terminal differentiation. A small CD200(+) CD45(-) BCC subpopulation that represents 1.63 ± 1.11% of all BCC cells resides in small clusters at the tumor periphery. By using reproducible in vivo xenograft growth assays, we determined that tumor initiating cell frequencies approximate one per 1.5 million unsorted BCC cells. The CD200(+) CD45(-) BCC subpopulation recreated BCC tumor growth in vivo with typical histological architecture and expression of sonic hedgehog-regulated genes. Reproducible in vivo BCC growth was achieved with as few as 10,000 CD200(+) CD45(-) cells, representing ~1,500-fold enrichment. CD200(-) CD45(-) BCC cells were unable to form tumors. These findings establish a platform to study the effects of Smoothened antagonists on BCC tumor initiating cell and also suggest that currently available anti-CD200 therapy be considered, either as monotherapy or an adjunct to Smoothened antagonists, in the treatment of inoperable BCC. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 4 |
| Volume Number | 110 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2013-01-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Antigens, CD Metabolism Carcinoma, Basal Cell Immunology Pathology Skin Neoplasms Animals Cell Differentiation Cell Proliferation Keratins Mice Mice, Inbred NOD Mice, Nude Mice, SCID Receptors, G-Protein-Coupled Antagonists & Inhibitors Transplantation, Heterologous Tumor Stem Cell Assay Research Support, N.I.H., Intramural Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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