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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Takase, Hinako M. Nusse, Roeland |
| Description | Author Affiliation: Takase HM ( Department of Developmental Biology, Stanford University, Stanford, CA 94305); Nusse R ( Department of Developmental Biology, Stanford University, Stanford, CA 94305); |
| Abstract | Spermatogonial stem cells (SSCs) fuel the production of male germ cells but the mechanisms behind SSC self-renewal, proliferation, and differentiation are still poorly understood. Using the Wnt target gene Axin2 and genetic lineage-tracing experiments, we found that undifferentiated spermatogonia, comprising SSCs and transit amplifying progenitor cells, respond to Wnt/ß-catenin signals. Genetic elimination of ß-catenin indicates that Wnt/ß-catenin signaling promotes the proliferation of these cells. Signaling is likely initiated by Wnt6, which is uniquely expressed by neighboring Sertoli cells, the only somatic cells in the seminiferous tubule that support germ cells and act as a niche for SSCs. Therefore, unlike other stem cell systems where Wnt/ß-catenin signaling is implicated in self-renewal, the Wnt pathway in the testis specifically contributes to the proliferation of SSCs and progenitor cells. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 11 |
| Volume Number | 113 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2016-06-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Spermatogonia Cytology Testis Metabolism Wnt Signaling Pathway Beta Catenin Animals Axin Protein Genetics Cell Differentiation Cell Proliferation Mice, Mutant Strains Mice, Transgenic Proto-Oncogene Proteins Sertoli Cells Stem Cells Wnt Proteins Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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