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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Chadderton, Jesseka La Gruta, Nicole L. Cukalac, Tania Handel, Andreas Thomas, Paul G. Doherty, Peter C. Turner, Stephen J. |
| Description | Author Affiliation: Cukalac T ( Department of Microbiology and Immunology, University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Parkville, VIC 3010, Australia.); |
| Abstract | The recall of memory CD8(+) cytotoxic T lymphocytes (CTLs), elicited by prior virus infection or vaccination, is critical for immune protection. The extent to which this arises as a consequence of stochastic clonal expansion vs. active selection of particular clones remains unclear. Using a parallel adoptive transfer protocol in combination with single cell analysis to define the complementarity determining region (CDR) 3 and CDR3ß regions of individual T-cell receptor (TCR) heterodimers, we characterized the antigen-driven recall of the same memory CTL population in three individual recipients. This high-resolution analysis showed reproducible enrichment (or diminution) of particular TCR clonotypes across all challenged animals. These changes in clonal composition were TCR - and ß chain-dependent and were directly related to the avidity of the TCR for the virus-derived peptide (p) + major histocompatibility complex class I molecule. Despite this shift in clonotype representation indicative of differential selection, there was no evidence of overall repertoire narrowing, suggesting a strategy to optimize CTL responses while safeguarding TCR diversity. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 4 |
| Volume Number | 111 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2014-01-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Antibody Affinity CD8-Positive T-Lymphocytes Immunology Orthomyxoviridae Infections Amino Acid Sequence Animals Clone Cells Immunologic Memory Immunophenotyping Mice, Inbred C57BL Molecular Sequence Data Complications Receptors, Antigen, T-Cell, Alpha-beta Reproducibility Of Results Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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