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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Weichselbaum, Ralph R. Roizman, Bernard Khodarev, Nikolai N. Huang, Lei Andrade, Jorge Parekh, Akash D. Liao, Zhengkai Xu, David Ranck, Mark C. Kumar, Kiran A. Golden, Daniel W. Huang, Xiaona Widau, Ryan C. Sood, Ravi F. Darga, Thomas E. Pitroda, Sean P. |
| Description | Author Affiliation: Widau RC ( Department of Radiation and Cellular Oncology and Ludwig Center for Metastasis Research, Center for Research Informatics, and The Marjorie B. Kovler Viral Oncology Laboratories, University of Chicago, Chicago, IL 60637.); |
| Abstract | An siRNA screen targeting 89 IFN stimulated genes in 14 different cancer cell lines pointed to the RIG-I (retinoic acid inducible gene I)-like receptor Laboratory of Genetics and Physiology 2 (LGP2) as playing a key role in conferring tumor cell survival following cytotoxic stress induced by ionizing radiation (IR). Studies on the role of LGP2 revealed the following: (i) Depletion of LGP2 in three cancer cell lines resulted in a significant increase in cell death following IR, (ii) ectopic expression of LGP2 in cells increased resistance to IR, and (iii) IR enhanced LGP2 expression in three cell lines tested. Studies designed to define the mechanism by which LGP2 acts point to its role in regulation of IFNß. Specifically (i) suppression of LGP2 leads to enhanced IFNß, (ii) cytotoxic effects following IR correlated with expression of IFNß inasmuch as inhibition of IFNß by neutralizing antibody conferred resistance to cell death, and (iii) mouse embryonic fibroblasts from IFN receptor 1 knockout mice are radioresistant compared with wild-type mouse embryonic fibroblasts. The role of LGP2 in cancer may be inferred from cumulative data showing elevated levels of LGP2 in cancer cells are associated with more adverse clinical outcomes. Our results indicate that cytotoxic stress exemplified by IR induces IFNß and enhances the expression of LGP2. Enhanced expression of LGP2 suppresses the IFN stimulated genes associated with cytotoxic stress by turning off the expression of IFNß. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 4 |
| Volume Number | 111 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2014-01-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Cell Survival Physiology DEAD-box RNA Helicases Neoplasms, Experimental Pathology RNA Helicases Radiation, Ionizing Animals Apoptosis Brain Neoplasms Metabolism Glioblastoma Interferon Type I Biosynthesis Mice Mice, Knockout Tumor Cells, Cultured Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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