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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Neretti, Nicola Antosh, Michael P. Katenka, Natallia Cooper, Leon N. Sun, Shouheng Andreev, Oleg A. Hasselbacher, Thomas Shrestha, Samana Fox, David Wijesinghe, Dayanjali D. Huang, Yun Hu Reshetnyak, Yana K. Lanou, Robert |
| Description | Author Affiliation: Antosh MP ( Institute for Brain and Neural Systems and Department of Physics, Brown University, Providence, RI 02912); Wijesinghe DD ( Physics Department, University of Rhode Island, Kingston, RI 02881); Shrestha S ( Physics Department, University of Rhode Island, Kingston, RI 02881); Lanou R ( Department of Physics, Brown University, Providence, RI 02912); Huang YH ( Department of Physics, Brown University, Providence, RI 02912); Hasselbacher T ( Institute for Brain and Neural Systems and.); Fox D ( Institute for Brain and Neural Systems and.); Neretti N ( Institute for Brain and Neural Systems and Department of Molecular Biology, Cell Biology and Biochemistry and.); Sun S ( Department of Chemistry, Brown University, Providence, RI 02912); Katenka N ( Department of Computer Science and Statistics, University of Rhode Island, Kingston, RI 02881.); Cooper LN ( Institute for Brain and Neural Systems and Department of Physics, Brown University, Providence, RI 02912); Andreev OA ( Physics Department, University of Rhode Island, Kingston, RI 02881); Reshetnyak YK ( Physics Department, University of Rhode Island, Kingston, RI 02881); |
| Abstract | Previous research has shown that gold nanoparticles can increase the effectiveness of radiation on cancer cells. Improved radiation effectiveness would allow lower radiation doses given to patients, reducing adverse effects; alternatively, it would provide more cancer killing at current radiation doses. Damage from radiation and gold nanoparticles depends in part on the Auger effect, which is very localized; thus, it is important to place the gold nanoparticles on or in the cancer cells. In this work, we use the pH-sensitive, tumor-targeting agent, pH Low-Insertion Peptide (pHLIP), to tether 1.4-nm gold nanoparticles to cancer cells. We find that the conjugation of pHLIP to gold nanoparticles increases gold uptake in cells compared with gold nanoparticles without pHLIP, with the nanoparticles distributed mostly on the cellular membranes. We further find that gold nanoparticles conjugated to pHLIP produce a statistically significant decrease in cell survival with radiation compared with cells without gold nanoparticles and cells with gold alone. In the context of our previous findings demonstrating efficient pHLIP-mediated delivery of gold nanoparticles to tumors, the obtained results serve as a foundation for further preclinical evaluation of dose enhancement. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 17 |
| Volume Number | 112 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2015-04-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Gamma Rays Membrane Proteins Metal Nanoparticles Chemistry Neoplasms Cell Line, Tumor Cell Survival Drug Effects Radiation Effects Pharmacology Metabolism Pathology Therapy Research Support, N.I.H., Extramural Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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