NDLI: Self-assembled aptamer-based drug carriers for bispecific cytotoxicity to cancer cells.

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Self-assembled aptamer-based drug carriers for bispecific cytotoxicity to cancer cells.

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Self-assembled aptamer-based drug carriers for bispecific cytotoxicity to cancer cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zhu, Guizhi Meng, Ling Ye, Mao Yang, Liu Sefah, Kwame O'Donoghue, Meghan B. Chen, Yan Xiong, Xiangling Huang, Jin Song, Erqun Tan, Weihong
Description	Country affiliation: United States Author Affiliation: Zhu G ( Department of Chemistry, Shands Cancer Center, UF Genetics Institute, University of Florida, Gainesville, Florida 32611-7200, USA.)
Abstract	Monovalent aptamers can deliver drugs to target cells by specific recognition. However, different cancer subtypes are distinguished by heterogeneous biomarkers and one single aptamer is unable to recognize all clinical samples from different patients with even the same type of cancers. To address heterogeneity among cancer subtypes for targeted drug delivery, as a model, we developed a drug carrier with a broader recognition range of cancer subtypes. This carrier, sgc8c-sgd5a (SD), was self-assembled from two modified monovalent aptamers. It showed bispecific recognition abilities to target cells in cell mixtures; thus broadening the recognition capabilities of its parent aptamers. The self-assembly of SD simultaneously formed multiple drug loading sites for the anticancer drug doxorubicin (Dox). The Dox-loaded SD (SD-Dox) also showed bispecific abilities for target cell binding and drug delivery. Most importantly, SD-Dox induced bispecific cytotoxicity in target cells in cell mixtures. Therefore, by broadening the otherwise limited recognition capabilities of monovalent aptamers, bispecific aptamer-based drug carriers would facilitate aptamer applications for clinically heterogeneous cancer subtypes that respond to the same cancer therapy.
File Format	HTM / HTML
ISSN	18614728
e-ISSN	1861471X
DOI	10.1002/asia.201101060
Journal	Chemistry - An Asian Journal
Issue Number	7
Volume Number	7
Language	English
Publisher	Wiley-VCH
Publisher Date	2012-06-01
Publisher Place	Germany
Access Restriction	Open
Subject Keyword	Research Support, N.i.h., Extramural Cell Survival Drug Therapy Cell Membrane Permeability Administration & Dosage Pharmacology Antibiotics, Antineoplastic Metabolism Doxorubicin Drug Effects Neoplasms Drug Delivery Systems Chemistry Aptamers, Nucleotide Cell Line, Tumor Discipline Chemistry Pharmacokinetics
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Biochemistry

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