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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kamberova, Gerda L. Morgan, Bruce A. Tabin, Clifford J. Lieberman, Daniel E. Kamberov, Yana G. Sabeti, Pardis C. Karlsson, Elinor K. |
| Description | Author Affiliation: Kamberov YG ( Department of Genetics, Harvard Medical School, Boston, MA 02115); Karlsson EK ( The Broad Institute of MIT and Harvard, Cambridge, MA 02142); Kamberova GL ( Department of Computer Science, Hofstra University, Hempstead, NY 11549.); Lieberman DE ( Department of Human Evolutionary Biology, Harvard University, Cambridge, MA 02138); Sabeti PC ( The Broad Institute of MIT and Harvard, Cambridge, MA 02142); Morgan BA ( Department of Dermatology, Harvard Medical School and Cutaneous Biology Research Center, Mass General Hospital, Charlestown, MA 02129); Tabin CJ ( Department of Genetics, Harvard Medical School, Boston, MA 02115); |
| Abstract | Among the unique features of humans, one of the most salient is the ability to effectively cool the body during extreme prolonged activity through the evapotranspiration of water on the skin's surface. The evolution of this novel physiological ability required a dramatic increase in the density and distribution of eccrine sweat glands relative to other mammals and a concomitant reduction of body hair cover. Elucidation of the genetic underpinnings for these adaptive changes is confounded by a lack of knowledge about how eccrine gland fate and density are specified during development. Moreover, although reciprocal changes in hair cover and eccrine gland density are required for efficient thermoregulation, it is unclear if these changes are linked by a common genetic regulation. To identify pathways controlling the relative patterning of eccrine glands and hair follicles, we exploited natural variation in the density of these organs between different strains of mice. Quantitative trait locus mapping identified a large region on mouse Chromosome 1 that controls both hair and eccrine gland densities. Differential and allelic expression analysis of the genes within this interval coupled with subsequent functional studies demonstrated that the level of En1 activity directs the relative numbers of eccrine glands and hair follicles. These findings implicate En1 as a newly identified and reciprocal determinant of hair follicle and eccrine gland density and identify a pathway that could have contributed to the evolution of the unique features of human skin. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 32 |
| Volume Number | 112 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2015-08-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Eccrine Glands Metabolism Genetic Variation Hair Follicle Animals Chromosome Mapping Chromosomes, Mammalian Genetics Crosses, Genetic Ectoderm Gene Expression Regulation Genome Mice, Inbred C57BL Multifactorial Inheritance Quantitative Trait Loci Quantitative Trait, Heritable Species Specificity Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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